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2C is a general name for the family of psychedelic and entheogenic phenethylamines containing methoxy groups on the 2 and 5 positions of the benzene ring. There is also usually a substitute on the 4 position to avoid excessive metabolism and thus be active on the CNS. Most of the currently known 2C's were first synthesized by Alexander Shulgin in the 70's and 80's, and recorded in his book, PiHKAL (Phenethylamines I Have Known And Loved). Dr. Shulgin also invented the term 2C, being an acronym for the 2 carbon atoms between the benzene ring and the amino group (the amphetamine counterparts are sometimes known as 3C's).


General structure of a 2C

Skeletal formula of 2C-T-7

Skeletal formula of 2C-T-21

Nomenclature R3 R4 2D Structure 3D Structure
2C-B HBlank.png Br Mini 2cb.png 2C-B-3d-sticks.png
2C-C H Cl Mini 2cc.png 2C-C-3d-sticks.png
2C-D H CH3 Mini 2cd.png 2C-D-3d-sticks.png
2C-E H CH2CH3 Mini 2ce.png 2C-E-3d-sticks.png
2C-F H F Mini 2cf.png 2C-F-3d-sticks.png
2C-G CH3 CH3 Mini 2cg.png 2C-G-3d-sticks.png
2C-G-3 (CH2)3 Mini 2cg3.png
2C-G-4 (CH2)4 Mini 2cg4.png
2C-G-N (CH)4 Mini 2cgn.png
2C-H H H Mini 2ch.png 2C-H-3d-sticks.png
2C-I H I Mini 2ci.png 2C-I-3d-sticks.png
2C-N H NO2 Mini 2cn.png 2C-N-3d-sticks.png
2C-O H OCH3 Mini 2co.png
2C-O-4 H OCH(CH3)2 Mini 2co4.png 2C-O-4-3d-sticks.png
2C-P H CH2CH2CH3 Mini 2cp.png 2C-P-3d-sticks.png
2C-SE H SeCH3 Mini 2cse.png 2C-SE-3d-sticks.png
2C-T H SCH3 Mini 2ct.png
2C-T-2 H SCH2CH3 Mini 2ct2.png
2C-T-4 H SCH(CH3)2 Mini 2ct4.png 2C-T-4-3d-sticks.png
2C-T-7 H S(CH2)2CH3 Mini 2ct7.png 2C-T-7-3d-sticks.png
2C-T-8 H SCH2CH(CH2)2 Mini 2ct8.png 2C-T-8-3d-sticks.png
2C-T-9 H SC(CH3)3 Mini 2ct9.png 2C-T-9-3d-sticks.png
2C-T-13 H S(CH2)2OCH3 Mini 2ct13.png 2C-T-13-3d-sticks.png
2C-T-15 H SCH(CH2)2 2ct15.png 2C-T-15-3d-sticks.png
2C-T-17 H SCH(CH3)CH2CH3 2ct17.png 2C-T-17-3d-sticks.png
2C-T-21 H S(CH2)2F Mini 2ct21.png 2C-T-21-3d-sticks.png
2C-TFM H CF3 Mini 2ctfm.png

See Also

Substituted Amphetamines

External Links

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