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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
- The correct title of this article is 5-HT1 receptor. It appears incorrectly here because of technical restrictions.
In the field of neurochemistry, 5-HT1 receptors are a subfamily of 5-HT receptors which bind the neurotransmitter and peripheral signal mediator serotonin, also known as 5-hydroxytryptamine (5-HT).[1]
Mode of action[]
5-HT1 receptors are G protein coupled receptors that Gi/Go-coupled. This causes a cellular decrease of cAMP.
Subtypes[]
Although working basically through the same mechanism, there are several 5-HT1 receptor subtypes (denoted A-F), each encoded by a separate gene. Furthermore each subtype has a somewhat different tissue distribution and binding preference for synthetic 5-HT1 agonist and antagonist ligands.
5-HT1A[]
- Main article: 5-HT1A receptor
| Gene | Agonists | Antagonists |
|---|---|---|
| HTR1A |
|
|
5-HT1A acts on the CNS, where it induces neuronal inhibition and controls behaviour, such as sleep, feeding, thermoregulation, aggression, anxiety.
5-HT1B[]
- Main article: 5-HT1B receptor
| Gene | Agonists | Antagonists |
|---|---|---|
| HTR1B |
|
|
5-HT1B acts on the CNS, where it induces presynaptic inhibition and behavioural effects. It also has vascular effects, such as pulmonary vasoconstriction.
5-HT1D[]
- Main article: 5-HT1D receptor
| Gene | Agonists | Antagonists |
|---|---|---|
| HTR1D |
|
|
5-HT1D acts on the CNS, and affects locomotion and anxiety. It also induces vascular vasoconstriction in the brain. Ergotamine works primarily through the 5-HT1B receptor, since the effect through the 5-HT1D receptor is contrary to the mode of action of ergotamine, i.e. vasoconstriction.
5-HT1E[]
- Main article: 5-HT1E receptor
| Gene | Agonists | Antagonists |
|---|---|---|
| HTR1E |
5-HT1F[]
- Main article: 5-HT1F receptor
| Gene | Agonists | Antagonists |
|---|---|---|
| HTR1F |
References[]
- ↑ Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP (1994). International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol. Rev. 46 (2): 157–203.
- ↑ Glennon RA, Hong SS, Dukat M, Teitler M, Davis K (1994). 5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist. J. Med. Chem. 37 (18): 2828–30.
External links[]
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