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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
- The correct title of this article is 5-HT2 receptor. It appears incorrectly here because of technical restrictions.
5-HT2 receptors are a family of 5-HT receptors, with the following members:
Multiple receptor subtypes of serotonin (5-HT) neurotransmitters with multiple physiologic functions have been recognized. The 5-HT-2 receptors mediate many of the central and peripheral physiologic functions of serotonin. Cardiovascular effects include contraction of blood vessels and shape changes in platelets; central nervous system effects include neuronal sensitization to tactile stimuli and mediation of hallucinogenic effects of phenylisopropylamine hallucinogens. [1]
5-HT2A receptors
- Main article: 5-HT2A receptor
This is the main excitatory receptor subtype among the GPCRs for serotonin (5-HT), although 5-HT2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbitofrontal cortex. This receptor was given importance first as the target of psychedelic drugs like LSD. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones.
5-HT2A also happens to be a necessary receptor for the spread of the human polyoma virus called JC virus.
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5-HT2B receptors
- Main article: 5-HT2B receptor
Function | Agonists | Antagonists |
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5-HT2C receptors
- Main article: 5-HT2C receptor
Function | Agonists | Antagonists |
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References
- ↑ [supplied by OMIM] Entrez Gene: HTR2B 5-hydroxytryptamine (serotonin) receptor 2B.
Cell physiology: cell signaling | |
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Key concepts |
Ligand - Cell signaling networks - Signal transduction - Apoptosis - Second messenger system (Ca2+ signaling, Lipid signaling) |
Processes |
Paracrine - Autocrine - Juxtacrine - Neurotransmitters - Endocrine (Neuroendocrine) |
Types of proteins |
Receptor (Transmembrane, Intracellular) - Transcription factor (General, Preinitiation complex, TFIID, TFIIH) - Adaptor protein |
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