Amoxapine

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Amoxapine chemical structure Amoxapine
IUPAC name
CAS number 14028-44-5	ATC code N06AA17
PubChem 2170	DrugBank APRD00142
Chemical formula	{{{chemical_formula}}}
Molecular weight	313.781
Bioavailability	?
Metabolism	Hepatic (cytochrome P450 system)
Elimination half-life	8-10 hours (30 hours for major metabolites)
Excretion	Renal
Pregnancy category	{{{pregnancy_category}}}
Legal status	{{{legal_status}}}
Routes of administration	Oral

Amoxapine (brand-names Asendin®, Asendis®, Defanyl®, Demolox®, Moxadil®) is a tetracyclic antidepressant of the dibenzoxazepine class. It is used in the treatment of depression, panic disorders and bipolar disorder.

Amoxapine is a strong reuptake inhibitor of norepinephrine and weak reuptake inhibitor of serotonin. One of its major metabolites, 7-hydroxyamoxapine, has a dopamine receptor blocking effect.

References

• Mosby Year-Book, Inc. (1995). Physician's GenRx: The Complete Drug Reference (5th Ed.). Riverside, CT: Denniston Publishing Co.
• Palfai, T. & Jankiewicz, H. (1997). Drugs and Human Behavior (2nd Ed.). Madison, WI: Brown & Benchmark.
• Hedges, D. & Burchfield, C. (2006). Mind, Brain, and Drug: An Introduction to Psychopharmacology. Boston, MA: Pearson.

fr:Amoxapine

ja:アモキサピン