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Angiotensin I converting enzyme
Symbol(s): ACE CD143, CD143
Locus: 17 q23
EC number
EntrezGene 1636
OMIM 106180
RefSeq NM_000789
UniProt P12821

Angiotensin I converting enzyme (ACE, EC is an exopeptidase.


It has two primary functions:

These two actions of ACE make it an ideal target in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy and type 2 diabetes mellitus. Inhibition of ACE (by ACE inhibitors) results in decreased formation of Angiotensin II (a far more potent vasoconstrictor than Angiotensin I) and decreased inactivation of bradykinin.


ACE is also known as:

  • peptidyl dipeptidase A
  • carboxycathepsin
  • kininase II (kinin-kallikrein system)
  • CD 143
  • ACE1


The ACE gene, ACE, encodes 2 isozymes. The somatic isozyme is expressed in many tissues, including vascular endothelial cells, epithelial kidney cells, and testicular Leydig cells, whereas the germinal is expressed only in sperm.

See also


  1. Physiology at MCG 7/7ch09/7ch09p16

External links

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