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The structure of Anisomycin
Anisomycin, also known as Flagecidin (IUPAC name: 3,4-Pyrrolidinediol, 2-[(4-methoxyphenyl)methyl]-, 3-acetate, (2R,3S,4S)-) is an antibiotic produced by Streptomyces griseolus which inhibits protein synthesis. Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis [1]. Anisomycin can activate stress-activated protein kinases, MAP kinase and other signal transduction pathways.
Anisomycin is inactive against bacteria.
Pharmacology[]
Anisomycin interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
Anisomycin is also mentioned as a potential psychiatric drug, as it may erase "short-range memory" [2].
Injection of anisomycin into the hippocampus has been proposed for selective removal of memories [3].
References[]
- 1.
Inhibitors of protein biosynthesis. II. Mode of action of anisomycin. 1967 Jul 10; PMID 6027796 Free text (PDF - 990K) - 2. Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration. 2002 Aug 21; PMID 12191817
- 3. Consolidation and reconsolidation of incentive learning in the amygdala. ; PMID 15673662 Free text
See also[]
External links[]
- anisomycin from Fermentek.
- Link page to external chemical sources.
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