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Anxiety has been linked to serotonin, particularly in terms of trait anxiety.
Noncoding polymorphisms[]
The promotor region of the SLC6A4 gene,that encodes the serotonin transporter contains a polymorphism with "short" and "long" repeats in a region: 5-HTT-linked polymorphic region (5-HTTLPR). The short variation leads to less transcription of SLC6A4, and it has been found that it can partly account for anxiety-related personality traits[1]. This polymorphism has been extensively investigated in over 300 scientific studies (as of 2006)[2]
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- Lesch, K.-P.; Bengel, D.; Heils, A.; Sabol, S. Z.; Greenberg, B. D.; Petri, S.; Benjamin, J.; Muller, C. R.; Hamer, D. H.; Murphy, D. L. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527-1530, PubMed ID : 8929413
- Schinka, J. A.; Busch, R. M.; Robichaux-Keene, N. (2004). A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Molec. Psychiat. 9: 197-202,
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- ↑ Klaus-Peter Lesch, Dietmar Bengel, Armin Heils, Sue Z. Sabol, Benjamin D. Greenberg, Susanne Petri, Jonathan Benjamin, Clemens R. Müller, Dean H. Hamer, Dennis L. Murphy (November 1996). Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region. Science 274 (5292).
- ↑ J.R. Wendland, B.J. Martin, M.R. Kruse, K.-P. Lesch, D.L. Murphy (2006). Simultaneous genotyping of four functional loci of human SLCA4, with a reappraisal of 5-HTTLPR and rs255531. Molecular Psychiatry: 1-3.