Arginine vasopressin receptor 1A

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Arginine vasopressin receptor 1A

Identifiers

Symbol(s)

AVPR1A; AVPR1

External IDs

OMIM: 600821 MGI: 1859216 Homologene: 568

Gene Ontology Molecular Function: • rhodopsin-like receptor activity • receptor activity • vasopressin receptor activity • protein kinase C binding Cellular Component: • endosome • plasma membrane • integral to plasma membrane Biological Process: • generation of precursor metabolites and energy • signal transduction • G-protein coupled receptor protein signaling pathway • phospholipase C activation • elevation of cytosolic calcium ion concentration • circulation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Entrez

552

54140

Ensembl

ENSG00000166148

ENSMUSG00000020123

Uniprot

P37288

Q3U1H9

Refseq

NM_000706 (mRNA) NP_000697 (protein)

NM_016847 (mRNA) NP_058543 (protein)

Location

Chr 12: 61.83 - 61.83 Mb

Chr 10: 121.85 - 121.86 Mb

Pubmed search

[1]

[2]

Arginine vasopressin receptor 1A (AVPR1A) is a protein that acts as receptor for arginine vasopressin. AVPR1A belongs to the subfamily of G-protein coupled receptors.

Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system.

The activity / genetic variants of the AVPR1 gene might be related to generosity and altruistic behavior.

See also

• Arginine vasopressin receptor 1B - AVPR1B, also called Arginine vasopressin receptor 3
• Arginine vasopressin receptor 2 - AVPR2

Further reading

• Thibonnier M, Coles P, Thibonnier A, Shoham M (2002). Molecular pharmacology and modeling of vasopressin receptors.. Prog. Brain Res. 139: 179-96.
• Cross SH, Charlton JA, Nan X, Bird AP (1994). Purification of CpG islands using a methylated DNA binding column.. Nat. Genet. 6 (3): 236-44.
• Hirasawa A, Shibata K, Kotosai K, Tsujimoto G (1994). Cloning, functional expression and tissue distribution of human cDNA for the vascular-type vasopressin receptor.. Biochem. Biophys. Res. Commun. 203 (1): 72-9.
• Thibonnier M, Auzan C, Madhun Z, et al. (1994). Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor.. J. Biol. Chem. 269 (5): 3304-10.
• Young WS, Kovács K, Lolait SJ (1993). The diurnal rhythm in vasopressin V1a receptor expression in the suprachiasmatic nucleus is not dependent on vasopressin.. Endocrinology 133 (2): 585-90.
• Thibonnier M, Graves MK, Wagner MS, et al. (1997). Structure, sequence, expression, and chromosomal localization of the human V1a vasopressin receptor gene.. Genomics 31 (3): 327-34.
• North WG, Fay MJ, Longo K, Du J (1998). Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma.. Peptides 18 (7): 985-93.
• North WG, Fay MJ, Longo KA, Du J (1998). Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide.. Cancer Res. 58 (9): 1866-71.
• North WG, Fay MJ, Du J (1999). MCF-7 breast cancer cells express normal forms of all vasopressin receptors plus an abnormal V2R.. Peptides 20 (7): 837-42.
• Tahara A, Tsukada J, Ishii N, et al. (1999). Comparison of vasopressin binding sites in human uterine and vascular smooth muscle cells.. Eur. J. Pharmacol. 378 (1): 137-42.
• Thibonnier M, Graves MK, Wagner MS, et al. (2000). Study of V(1)-vascular vasopressin receptor gene microsatellite polymorphisms in human essential hypertension.. J. Mol. Cell. Cardiol. 32 (4): 557-64.
• Berrada K, Plesnicher CL, Luo X, Thibonnier M (2000). Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation.. J. Biol. Chem. 275 (35): 27229-37.
• Kim SJ, Young LJ, Gonen D, et al. (2002). Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism.. Mol. Psychiatry 7 (5): 503-7.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903.
• Tahtaoui C, Balestre MN, Klotz P, et al. (2003). Identification of the binding sites of the SR49059 nonpeptide antagonist into the V1a vasopressin receptor using sulfydryl-reactive ligands and cysteine mutants as chemical sensors.. J. Biol. Chem. 278 (41): 40010-9.
• Hawtin SR, Wesley VJ, Simms J, et al. (2004). An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist.. Eur. J. Biochem. 270 (23): 4681-8.
• Terrillon S, Barberis C, Bouvier M (2004). Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns.. Proc. Natl. Acad. Sci. U.S.A. 101 (6): 1548-53.
• Wassink TH, Piven J, Vieland VJ, et al. (2005). Examination of AVPR1a as an autism susceptibility gene.. Mol. Psychiatry 9 (10): 968-72.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14 (10B): 2121-7.

External links

• IUPHAR GPCR Database - Arginine vasopressin receptor V_1A