|DOPA decarboxylase (aromatic L-amino acid decarboxylase)|
It catalyzes several different decarboxylation reactions:
- L-DOPA to dopamine - a neurotransmitter
- 5-HTP to serotonin (5-HT) - also a neurotransmitter
- tryptophan to tryptamine - a precursor to many alkaloids found in plants and animals
As a rate limiting step
In normal dopamine and serotonin (5-HT) neurotransmitter synthesis, AAAD is not the rate-limiting step in either reaction. However, AAAD becomes the rate-limiting step of dopamine synthesis in patients treated with L-DOPA (such as in Parkinson's Disease), and the rate-limiting step of serotonin synthesis in people treated with 5-HTP (such as in mild depression or dysthymia).
AAAD is the rate-limiting enzyme in the formation of biogenic trace amines.
- Aromatic amino acids
- Lisa J. Scherer, John D. McPherson, John J. Wasmuth and J. Lawrence Marsh (June 1992). Human dopa decarboxylase: Localization to human chromosome 7p11 and characterization of hepatic cDNAs. Genomics 13 (2): 469–471.
Carbon-carbon lyases (EC 4.1)
Pyruvate decarboxylase -Oxaloacetate decarboxylase - Acetoacetate decarboxylase - Malonyl-CoA decarboxylase - Glutamate decarboxylase - Ornithine decarboxylase - Lysine decarboxylase - Phosphoribosylaminoimidazole carboxylase - Histidine decarboxylase - Uridine monophosphate synthetase/Orotidine 5'-phosphate decarboxylase - Aromatic L-amino acid decarboxylase - Phosphoenolpyruvate carboxylase - Pyrophosphomevalonate decarboxylase - Uroporphyrinogen III decarboxylase - RuBisCO - Phosphoenolpyruvate carboxykinase - Adenosylmethionine decarboxylase
Aldolase A/Aldolase B - 2-hydroxyphytanoyl-CoA lyase
Amino acid metabolism enzymes
Phenylalanine hydroxylase - Tyrosine aminotransferase - 4-Hydroxyphenylpyruvate dioxygenase - Homogentisate 1,2-dioxygenase - Fumarylacetoacetate hydrolase
Branched-chain alpha-keto acid dehydrogenase complex - Isovaleryl coenzyme A dehydrogenase - Methylcrotonyl-CoA carboxylase
Branched-chain alpha-keto acid dehydrogenase complex
Methionine adenosyltransferase - Adenosylhomocysteinase - (or MTR) - Cystathionine beta synthase - Cystathionine gamma-lyase
Propionyl-CoA carboxylase - Methylmalonyl-CoA mutase
Tryptophan hydroxylase - Aromatic L-amino acid decarboxylase - 5-hydroxyindole-O-methyltransferase
Asparaginase/Asparagine synthetase - Aspartate transaminase
Glutaminase - Glutamate decarboxylase
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