Benperidol chemical structure | |
1-[1-[4-(4-fluorophenyl)-4-oxo-butyl] -4-piperidyl]-3H-benzoimidazol-2-one IUPAC name | |
CAS number 983-42-6 |
ATC code |
PubChem 16363 |
DrugBank [1] |
Chemical formula | {{{chemical_formula}}} |
Molecular weight | 381.443g/mol |
Bioavailability | |
Metabolism | |
Elimination half-life | |
Excretion | |
Pregnancy category | |
Legal status | |
Routes of administration | Oral |
Benperidol is a drug which is a highly potent butyrophenone derivative. It is in fact the most potent neuroleptic on the european market, with chlorpromazine equivalency as high as 75 to 100 (about 150 to 200% potency in terms of dose compared to haloperidol).[1]. It is an antipsychotic, which can be used for the treatment of schizophrenia[2], but it is primarily used to control deviant, antisocial hypersexual behaviour[3], and is sometimes prescribed to sex offenders as a condition of their parole, as an alternative to anti-androgen drugs such as cyproterone.[4]
Benperidol was discovered at Janssen Pharmaceutica in 1961.
References[]
- ↑ Möller; Müller; Bandelow: Neuroleptika, 2001, WVG; ISBN 3-8047-1773-X (in German)
- ↑ Bobon J, Collard J, Lecoq R, Benperidol and promazine: a "double blind" comparative study in mental geriatrics, Acta Neurol Belg. 1963 Oct;63:839-43.
- ↑ British National Formulary (49th), British Medical Association 2005 p 183
- ↑ Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ., Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers, Journal of Endocrinology. 1975 Nov;67(2):179-88.
Psycholeptics: antipsychotics (N05A)
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Phenothiazine typical antipsychotics | Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine |
Other typical antipsychotics | Indoles (Molindone) • Butyrophenones (Azaperone, Benperidol, Droperidol, Haloperidol) • Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) • diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) • other (Loxapine) |
Atypical antipsychotics | Butyrophenones (Melperone) • Indoles (Sertindole, Ziprasidone) • Benzamides (Sulpiride, Remoxipride, Amisulpride) • diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) • other (Aripiprazole, Risperidone, Paliperidone, Zotepine) |