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The Bezold–Jarisch reflex involves a variety of cardiovascular and neurological processes which cause hypopnea (overly shallow breathing or an abnormally low respiratory rate) and bradycardia (abnormally low resting heart rate).
Prolonged upright posture results in some degree of pooling of blood in the lower extremities that can lead to diminished intracardiac volume.
This phenomenon is accentuated if the individual is dehydrated.
However, pressure receptors in the wall and trabeculae of the underfilled left ventricle may then sense stimuli, indicating high-pressure C-fiber afferent nerves from these receptors.
It usually occurs in nitrate therapy and use of serotonin agonists.
It is named for Albert von Bezold and Adolf Jarisch Junior.
- Salo LM, Woods RL, Anderson CR, McAllen RM (August 2007). Nonuniformity in the von Bezold-Jarisch reflex. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 (2): R714–20.
- eMedicine - Syncope : Article by M Silvana Horenstein, MD
- Who Named It synd/3165
Nervous system physiology: neurophysiology - reflex
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