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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
style="background: #F8EABA; text-align: center;" colspan="2" | Butyrophenone |
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1-cyclohexylbutan-1-one | |
Identifiers | |
CAS number | |
PubChem | 10315 |
SMILES | CCCC(=O)C1=CC=CC=C1 |
Properties | |
Molecular formula | C10H12O |
Molar mass | 148.202 |
Hazards | |
style="background: #F8EABA; text-align: center;" colspan="2" | Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
Butyrophenone is a compound, and butyrophenones are a class of pharmaceutical drugs derived from that compound that block dopamine receptors and are used to treat various pyschiatric disorders such as schizophrenia, as well as acting as moderately effective antiemetics.
Examples include:
- Haloperidol, the most widely used drug in this class
- Droperidol, often used for neuroleptanalgesic anesthesia and sedation in intensive care treatment
- Benperidol, the most potent commonly used antipsychotic (~ 200 times more potent as chlorpromazine)
- Triperidol, a highly potent antipsychotic (100 times more potent than chlorpromazine)
- Melperone, a weakly potent antipsychotic, in Europe commonly used for treatment of insomnia, confusional states, psychomotor agitation, and delirium, particular in geriatric patients
- Lenperone
- Domperidone, used to suppress nausea and vomiting. It has also been used to stimulate lactation.
The atypical antipsychotic risperidone, although not a butyrophenone, was developed with the structures of benperidol and lenperone as a basis.
Psycholeptics: antipsychotics (N05A)
| |
---|---|
Phenothiazine typical antipsychotics | Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine |
Other typical antipsychotics | Indoles (Molindone) • Butyrophenones (Azaperone, Benperidol, Droperidol, Haloperidol) • Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) • diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) • other (Loxapine) |
Atypical antipsychotics | Butyrophenones (Melperone) • Indoles (Sertindole, Ziprasidone) • Benzamides (Sulpiride, Remoxipride, Amisulpride) • diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) • other (Aripiprazole, Risperidone, Paliperidone, Zotepine) |
de:Butyrophenone zh:丁酰苯类抗精神分裂药
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