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cholecystokinin A receptor | |
---|---|
Symbol(s): | CCKAR |
Locus: | 4 p15.2 -p15.1 |
EC number | [1] |
EntrezGene | 886 |
OMIM | 118444 |
RefSeq | NM_000730 |
UniProt | P32238 |
cholecystokinin B receptor | |
---|---|
Symbol(s): | CCKBR |
Locus: | 11 p15.4 |
EC number | [2] |
EntrezGene | 887 |
OMIM | 118445 |
RefSeq | NM_176875 |
UniProt | P32239 |
Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors. There are two different subtypes CCK1 and CCK2. They are ~50% homologous. The CCK1 receptor binds mostly to Cholecystokinin while CCK2 also binds to gastrin. They are mostly involved in various digestive functions like gastrin-stimulated gastric acid secretion, gastric emptying and gut motility. In the brain, CCK functions as a neuropeptide and CCK receptors are involved in nociception, anxiety, memory and hunger.
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