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Chloride channels are a superfamily of poorly understood ion channels consisting of approximately 13 members.
Chloride channels are important for setting cell resting membrane potential and maintaining proper cell volume. These channels conduct Cl- as well as other anions such as HCO3-, I-, SCN-, and NO3-. The structure of these channels is also not other known channels. Chloride channel subunits contain between 1 and 12 transmembrane segments. Some members of this family are activated by voltage, while others are activated by Ca2+, extracellular ligands, and pH among other modulators.
- CLCN1, CLCN2, CLCN3, CLCN4, CLCN5, CLCN6, CLCN7
- CLCNKA, CLCNKB
- CLIC1, CLIC2, CLIC3, CLIC4, CLIC5, CLIC6
- CLNS1A, CLNS1B
- CLCA1, CLCA2, CLCA3, CLCA4
- Cystic fibrosis transmembrane conductance regulator
- Thomsen disease
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