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cholecystokinin A receptor
Symbol(s): CCKAR
Locus: 4 p15.2 -p15.1
EC number [1]
EntrezGene 886
OMIM 118444
RefSeq NM_000730
UniProt P32238
cholecystokinin B receptor
Symbol(s): CCKBR
Locus: 11 p15.4
EC number [2]
EntrezGene 887
OMIM 118445
RefSeq NM_176875
UniProt P32239

Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin.[1] There are two different subtypes CCKA and CCKB which are ~50% homologous:[2]

protein gene tissue distribution preferred ligand function
CCKA (CCK1) CCKAR primarily gastrointestinal tract, lesser amounts in the CNS sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK stimulation of gastric acid secretion, gastric emptying and gut motility
CCKB (CCK2) CCKBR primarily CNS, lesser amounts in the gastrointestinal track gastrin ≈ CCK (receptor does not descriminate between sulfated and nonsulfated peptides) regulation of nociception, anxiety, memory and hunger


  1. Noble F, Wank SA, Crawley JN, Bradwejn J, Seroogy KB, Hamon M, Roques BP (1999). International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol. Rev. 51 (4): 745–81.
  2. Dufresne M, Seva C, Fourmy D (2006). Cholecystokinin and gastrin receptors. Physiol. Rev. 86 (3): 805–47.

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