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==Functions== |
==Functions== |
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| − | In many species, including [[ |
+ | In many species, including [[amphibian]]s, [[reptile]]s, [[rodents]] and [[birds]], corticosterone is a main [[glucocorticoid]],<ref name="urle.hormone | The Hormones : Corticoids">{{cite web |url=http://e.hormone.tulane.edu/learning/corticoids.html |title=e.hormone | The Hormones : Corticoids |format= |work= |accessdate=2009-04-09}}</ref> involved in regulation of fuel, [[immune]] reactions, and [[stress (medicine)|stress]] responses. |
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| ⚫ | However, in [[humans]], corticosterone is produced primarily in the [[zona fasciculata]] of the [[adrenal cortex]]. It has only weak [[glucocorticoid]] and [[mineralocorticoid]] potencies in humans and is important mainly as an intermediate in the [[steroidogenic pathway]] from [[pregnenolone]] to [[aldosterone]]. Corticosterone is converted to aldosterone by [[aldosterone synthase]], found only in the mitochondria of glomerulosa cells. Glomerulosa cells are found in the [[Zona glomerulosa]], which is the most superficial region of endocrine cells in the [[adrenal cortex]]. |
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| + | ==Release or generation mechanisms== |
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| + | One example of a release pathway relates to [[UV-B]] stimulation on the skins of certain [[amphibian]]s such as the [[Rough-skinned Newt]], ''[[Taricha granulosa]]''; this trigger seems to cause the internal generation of corticosterone in that species.<ref>C. Michael Hogan (2008) ''Rough-skinned Newt (Taricha granulosa)'', Globaltwitcher, ed. Nicklas Stromberg [http://www.globaltwitcher.com/artspec_information.asp?thingid=43182]</ref> |
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| + | ==References== |
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| + | {{reflist}} |
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| ⚫ | However, in [[humans]], corticosterone is produced primarily in the [[zona |
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==Additional images== |
==Additional images== |
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| + | [[Category:Adrenal cortex hormones]] |
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[[Category:Corticosteroids]] |
[[Category:Corticosteroids]] |
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Latest revision as of 11:09, 27 November 2010
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Corticosterone is a 21 carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Functions
In many species, including amphibians, reptiles, rodents and birds, corticosterone is a main glucocorticoid,_The_Hormones_:_Corticoids-1|[1] involved in regulation of fuel, immune reactions, and stress responses.
However, in humans, corticosterone is produced primarily in the zona fasciculata of the adrenal cortex. It has only weak glucocorticoid and mineralocorticoid potencies in humans and is important mainly as an intermediate in the steroidogenic pathway from pregnenolone to aldosterone. Corticosterone is converted to aldosterone by aldosterone synthase, found only in the mitochondria of glomerulosa cells. Glomerulosa cells are found in the Zona glomerulosa, which is the most superficial region of endocrine cells in the adrenal cortex.
Release or generation mechanisms
One example of a release pathway relates to UV-B stimulation on the skins of certain amphibians such as the Rough-skinned Newt, Taricha granulosa; this trigger seems to cause the internal generation of corticosterone in that species.[2]
References
- _The_Hormones_:_Corticoids_1-0|↑ e.hormone | The Hormones : Corticoids. URL accessed on 2009-04-09.
- ↑ C. Michael Hogan (2008) Rough-skinned Newt (Taricha granulosa), Globaltwitcher, ed. Nicklas Stromberg [1]
Additional images
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