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Cyclopyrrolones are a family of hypnotic and anxiolytic nonbenzodiazepine drugs with similar pharmacological profiles to the benzodiazepine derivatives.

Although cyclopyrrolones are chemically unrelated to benzodiazepines, they function via the benzodiazepine receptor/GABA neurotransmitter. The best known cyclopyrrolone derivatives are zopiclone (Imovane) and its enantiomer eszopiclone (Lunesta), which are used to treat insomnia, and have a known potential for abuse. Other cyclopyrrolone derivatives include suriclone, pagoclone, pazinaclone and suproclone.

  • Cyclopyrrolones
    • eszopiclone - hypnotic (Lunesta)
    • zopiclone - hypnotic (Imovane)
    • pagoclone - anxiolytic
    • suriclone - anxiolytic
    • pazinaclone - anxiolytic
    • suproclone - anxiolytic

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