Drug sensitivity

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Drugs

Drug type

Designer drugs Dissociative drug Hallucinogenic drugs Nonprescription drugs Nootropic drugs Pharmaceutical drug Psychedelic drug Psychoactive drug Prescription drugs

Drug usage

Adverse drug reaction Drug abstinance Drug administration methods Drug allergies Drug discrimination Drug induced congenital disorders Drug interactions Drug metabolism Epidemiology of drug use Recreational drug use

Drug abuse

Codependency Drug abuse liability Drug addiction Drug dependency Drug dosages Drug induced hallucinations Drug laws Drug legalization Drug overdoses Drug sensitivity Drug tolerance Drug usage attitudes Drug withdrawal Laxative abuse Intravenous drug use Illegal drug distribution Needle exchange programs Needle sharing Poly drug abuse

Drug treatment

DANOS Drug abuse psychology Drug abuse prevention Drug augmentation Drug education Drug rehabilitation Drug self administration Drug therapy Drug usage screening Psychopharmacology Self medication Side effects (drug)

Drug sensitivity or Drug intolerance is a lower threshold to the normal pharmacologic action of a drug. It is not to be confused with drug allergy. Drug intolerance is uncommon and idiopathic, thus extremely difficult to predict except in persons with a prior history or a family history of intolerance to that specific drug. Some drug intolerances are known to result from genetic variants of drug metabolism.

Examples

• Tinnitus after a normal dose of aspirin
• Liver failure (possibly also kidney failure) after a normal dose of acetaminophen
• Fatal poisoning in a breastfed newborn baby due to normal use of codeine by the mother

Analgesic intolerance

Intolerance to analgesics, particularly NSAIDs, is relatively common. Its cause is believed to be variation in the metabolism of arachidonic acid. Symptoms include chronic rhinosinusitis with nasal polyps, asthma, gastrointestinal ulcers, angioedema, and urticaria.

See also

• Contraindication
• Drug tolerance
• Food intolerance