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Brain: Fastigial nucleus
Sagittal section through right cerebellar hemisphere. The right olive has also been cut sagitally. (Fastigial nucleus visible but not labeled.)
Latin nucleus fastigii
Gray's subject #187 796
Part of cerebellum
BrainInfo/UW hier-687
MeSH [1]

The fastigial nucleus or nucleus fastigii refers specifically to the concentration of gray matter nearest to the middle line at the anterior end of the superior vermis, and immediately over the roof of the fourth ventricle, from which it is separated by a thin layer of white matter.[1] It is smaller than the nucleus dentatus, but somewhat larger than the nucleus emboliformis and nucleus globosus, the other two independent centers of gray matter in the cerebellum.

Relations and function

The fastigial nucleus receives its afferent input from the flocculonodular lobe and the vermis. Most of its efferent connections travel via the inferior cerebellar peduncle to the vestibular nuclei, which is located at the junction of the pons and the medulla oblongata.

The fastigial nucleus deals with antigravity muscle groups and other synergies involved with standing and walking.[2]

The fastigial nucleus contains excitatory axons which project beyond the cerebellum, unlike the Purkinje cells that convey the purely-inhibitory output of the cerebellar cortex. The likely neurotransmitters of the excitatory fastigial nucleus axons are glutamate and aspartate.

The Purkinje cells of the cerbellar cortex project into the deep cerebellar nuclei and inhibit the excitatory output system.


  1. John K. Harting, Ph.D. (1997). The Global Cerebellum '97. University of Wisconsin Medical School. URL accessed on 2007-06-28.
  2. James D. Geyer, Janice M. Keating, Daniel C. Potts (1998). Neurology for the Boards, Lippincott-Raven.

External links

This article was originally based on an entry from a public domain edition of Gray's Anatomy. As such, some of the information contained herein may be outdated. Please edit the article if this is the case, and feel free to remove this notice when it is no longer relevant.


de:Nucleus fastigii

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