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Fungal pheromone mating factor receptors form a distinct family of G-protein coupled receptors.

Mating factor receptors, STE2 and STE3 are integral membrane proteins that may be involved in the response to mating factors on the cell membrane[1][2][3]. The amino acid sequences of both receptors contain high proportions of hydrophobic residues grouped into 7 domains, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins.


  1. Nakayama N, Miyajima A, Arai K (1985). Nucleotide sequences of STE2 and STE3, cell type-specific sterile genes from Saccharomyces cerevisiae. EMBO J. 4: 2643-2648.
  2. Burkholder AC, Hartwell LH (1985). The yeast alpha-factor receptor: structural properties deduced from the sequence of the STE2 gene. Nucleic Acids Res. 13 (23): 8463-8475.
  3. Herskowitz I, Marsh L (1988). STE2 protein of Saccharomyces kluyveri is a member of the rhodopsin/beta-adrenergic receptor family and is responsible for recognition of the peptide ligand alpha factor. Proc. Natl. Acad. Sci. U.S.A. 85 (11): 3855-3859.