GABA transporter 1

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)

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GABA transporter 1 (GAT-1) also known as sodium- and chloride-dependent GABA transporter 1 is a protein that in humans is encoded by the SLC6A1 gene.^[1]^[2]

Function[]

GAT-1 a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft.^[3]

Interactions[]

SLC6A1 has been shown to interact with STX1A.^[4]^[5]^[6]

References[]

↑ Huang F, Shi LJ, Heng HH, Fei J, Guo LH (February 1996). Assignment of the human GABA transporter gene (GABATHG) locus to chromosome 3p24-p25. Genomics 29 (1): 302–4.
↑ Entrez Gene: SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1.
↑ Hirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA (January 2009). Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity. Pharmacogenet. Genomics 19 (1): 53–65.
↑ Beckman, M L, Bernstein E M, Quick M W (August 1998). Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A. J. Neurosci. 18 (16): 6103–12.
↑ Quick, Michael W (April 2002). Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner. Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5686–91.
↑ Deken, S L, Beckman M L, Boos L, Quick M W (October 2000). Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A. Nat. Neurosci. 3 (10): 998–1003.

Further reading[]

Nelson H, Mandiyan S, Nelson N (1990). Cloning of the human brain GABA transporter.. FEBS Lett. 269 (1): 181–4.
Bennett ER, Kanner BI (1997). The membrane topology of GAT-1, a (Na+ + Cl-)-coupled gamma-aminobutyric acid transporter from rat brain.. J. Biol. Chem. 272 (2): 1203–10.
Bismuth Y, Kavanaugh MP, Kanner BI (1997). Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition.. J. Biol. Chem. 272 (26): 16096–102.
DeFelipe J, González-Albo MC (1998). Chandelier cell axons are immunoreactive for GAT-1 in the human neocortex.. Neuroreport 9 (3): 467–70.
Conti F, Melone M, De Biasi S, et al. (1998). Neuronal and glial localization of GAT-1, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in human cerebral cortex: with a note on its distribution in monkey cortex.. J. Comp. Neurol. 396 (1): 51–63.
Beckman ML, Bernstein EM, Quick MW (1998). Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A.. J. Neurosci. 18 (16): 6103–12.
Augood SJ, Waldvogel HJ, Münkle MC, et al. (1999). Localization of calcium-binding proteins and GABA transporter (GAT-1) messenger RNA in the human subthalamic nucleus.. Neuroscience 88 (2): 521–34.
Ong WY, Yeo TT, Balcar VJ, Garey LJ (2000). A light and electron microscopic study of GAT-1-positive cells in the cerebral cortex of man and monkey.. J. Neurocytol. 27 (10): 719–30.
Deken SL, Beckman ML, Boos L, Quick MW (2000). Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A.. Nat. Neurosci. 3 (10): 998–1003.
Whitworth TL, Quick MW (2001). Substrate-induced regulation of gamma-aminobutyric acid transporter trafficking requires tyrosine phosphorylation.. J. Biol. Chem. 276 (46): 42932–7.
Hachiya Y, Takashima S (2002). Development of GABAergic neurons and their transporter in human temporal cortex.. Pediatr. Neurol. 25 (5): 390–6.
Quick MW (2002). Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner.. Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5686–91.
Kanner BI (2003). Transmembrane domain I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport modes.. J. Biol. Chem. 278 (6): 3705–12.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
Zomot E, Kanner BI (2003). The interaction of the gamma-aminobutyric acid transporter GAT-1 with the neurotransmitter is selectively impaired by sulfhydryl modification of a conformationally sensitive cysteine residue engineered into extracellular loop IV.. J. Biol. Chem. 278 (44): 42950–8.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 36 (1): 40–5.
Zhou Y, Bennett ER, Kanner BI (2004). The aqueous accessibility in the external half of transmembrane domain I of the GABA transporter GAT-1 Is modulated by its ligands.. J. Biol. Chem. 279 (14): 13800–8.
Hu JH, Ma YH, Jiang J, et al. (2004). Cognitive impairment in mice over-expressing gamma-aminobutyric acid transporter 1 (GAT1).. Neuroreport 15 (1): 9–12.
Korkhov VM, Farhan H, Freissmuth M, Sitte HH (2005). Oligomerization of the {gamma}-aminobutyric acid transporter-1 is driven by an interplay of polar and hydrophobic interactions in transmembrane helix II.. J. Biol. Chem. 279 (53): 55728–36.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Membrane transport protein: neurotransmitter transporters

Glutamate - Monoamine (DAT, NET, SERT) - Vesicular monoamine (VMAT1, VMAT2) - Vesicular acetylcholine

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[pmid8530094-1] Huang F, Shi LJ, Heng HH, Fei J, Guo LH (February 1996). Assignment of the human GABA transporter gene (GABATHG) locus to chromosome 3p24-p25. Genomics 29 (1): 302–4.

[entrez-2] Entrez Gene: SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1.

[pmid19077666-3] Hirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA (January 2009). Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity. Pharmacogenet. Genomics 19 (1): 53–65.

[pmid9698305-4] Beckman, M L, Bernstein E M, Quick M W (August 1998). Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A. J. Neurosci. 18 (16): 6103–12.

[pmid11960023-5] Quick, Michael W (April 2002). Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner. Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5686–91.

[pmid11017172-6] Deken, S L, Beckman M L, Boos L, Quick M W (October 2000). Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A. Nat. Neurosci. 3 (10): 998–1003.

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v·d·e Membrane proteins, carrier proteins: membrane transport proteins
ABC-transporter	A1, A12, B1, B2-3, B4, B5, B11, C4, C6, C8-9, D1, E1
Solute carrier	1A1-7, 1A3, 2A1, 2A2, 2A3, 2A4, 3A1, 3A2, 4A1, 5A1-2, 5A5, 6A2, 6A3, 6A4, 7A5, 7A9, 8A1-3, 9A3, 11A2, 12A1-2, 12A3, 17A6-8, 18A1, 18A2, 18A3, 19A2, 19A3, 22A5, 24A1-2, 24A5, 25A4-6, 25A13, 25A15, 25A20, 26A2, 26A4, 34A1, 39A4, 40A1
Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT8
Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Karyopherin)

GABA transporter 1

Contents

Function[]

Interactions[]

See also[]

References[]

Further reading[]

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