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guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Symbol(s): GNAI1
Locus: 7 q21 -q22
EC number [1]
EntrezGene 2770
OMIM 139310
RefSeq NM_002069
UniProt P63096
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Symbol(s): GNAI2 GNAI2B
Locus: 3 p21
EC number [2]
EntrezGene 2771
OMIM 139360
RefSeq NM_002070
UniProt P04899
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
Symbol(s): GNAI3
Locus: 1 p13
EC number [3]
EntrezGene 2773
OMIM 139370
RefSeq NM_006496
UniProt P08754

Gi alpha subunit (or Gi/G0 or Gi protein) is a heterotrimeric G protein subunit which inhibits the production of cAMP from ATP.

Receptors[]

The following G-protein coupled receptors couple to the Gi subunit:

Function[]

Further reading: function of cAMP-dependent protein kinase

Gi inhibits the production of cAMP from ATP, which, in turn, results in decreased activity of cAMP-dependent protein kinase. Thus, the ultimate effect of Gi is thus the opposite of cAMP-dependent protein kinase, which can be found at function of cAMP-dependent protein kinase.

Types[]

There are several types of Gi: Gia1, Gia2, Gia3 and Gia4

Gia1[]

Gia1 or Gi1 is encoded by the gene GNAI1.

Gia2[]

Gia2 or Gi2 is encoded by the gene GNAI2.

Gia3[]

Gia3 or Gi3 is encoded by the gene GNAI3.

See also[]

External links[]


Template:GTPases

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