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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | |
---|---|
Symbol(s): | GNAI1 |
Locus: | 7 q21 -q22 |
EC number | [1] |
EntrezGene | 2770 |
OMIM | 139310 |
RefSeq | NM_002069 |
UniProt | P63096 |
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | |
---|---|
Symbol(s): | GNAI2 GNAI2B |
Locus: | 3 p21 |
EC number | [2] |
EntrezGene | 2771 |
OMIM | 139360 |
RefSeq | NM_002070 |
UniProt | P04899 |
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | |
---|---|
Symbol(s): | GNAI3 |
Locus: | 1 p13 |
EC number | [3] |
EntrezGene | 2773 |
OMIM | 139370 |
RefSeq | NM_006496 |
UniProt | P08754 |
Gi alpha subunit (or Gi/G0 or Gi protein) is a heterotrimeric G protein subunit which inhibits the production of cAMP from ATP.
Receptors[]
The following G-protein coupled receptors couple to the Gi subunit:
- 5-HT receptor type 1
- Adenosine receptor A1 and A3
- Prostaglandins
Function[]
Further reading: function of cAMP-dependent protein kinase
Gi inhibits the production of cAMP from ATP, which, in turn, results in decreased activity of cAMP-dependent protein kinase. Thus, the ultimate effect of Gi is thus the opposite of cAMP-dependent protein kinase, which can be found at function of cAMP-dependent protein kinase.
Types[]
There are several types of Gi: Gia1, Gia2, Gia3 and Gia4
Gia1[]
Gia1 or Gi1 is encoded by the gene GNAI1.
Gia2[]
Gia2 or Gi2 is encoded by the gene GNAI2.
Gia3[]
Gia3 or Gi3 is encoded by the gene GNAI3.
See also[]
External links[]
Template:GTPases
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