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| GNAS complex locus | |
|---|---|
| Symbol(s): | GNAS GNAS1 |
| Locus: | 20 q13.2 -13.3 |
| EC number | [1] |
| EntrezGene | 2778 |
| OMIM | 139320 |
| RefSeq | NM_000516 |
| UniProt | Q5JWF2 |
The Gs alpha subunit (or Gs protein) is a heterotrimeric G protein subunit which activates adenylate cyclase. Researchers have discovered that a change in the location of this protein in the brain could serve as a biomarker for depression, allowing a simple, rapid, laboratory test to identify patients with depression. [1]
Receptors[]
The G-protein coupled receptors that couple to this kind of G-protein are for example:
- 5-HT receptors type 4 and 7
- D1-like dopamine receptors
- β-adrenergic receptors
- M1 receptor (primarily Gq-coupled)
- Prostaglandin D2 receptor
- Adenosine receptor A2a and A2b
- Calcitonin receptor
- Calcitonin gene-related peptide receptor
Function[]
- Main article: function of cAMP-dependent protein kinase
The general function of Gs is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn activates cAMP-dependent protein kinase. Further effects of Gs is thus found in function of cAMP-dependent protein kinase.
See also[]
References[]
External links[]
Template:GTPases
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