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Hexobarbital chemical structure

IUPAC name
CAS number
ATC code

N01AF02 .

Chemical formula {{{chemical_formula}}}
Molecular weight 236.267 g/mol
Elimination half-life
Pregnancy category
Legal status
Routes of administration

Hexobarbital is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s-1950s as an agent for inducing anesthesia for surgery and has a relatively fast onset of effects and short duration of action. However it can be difficult to control the depth of anesthesia with hexobarbital which makes it quite dangerous, and it has now been replaced by safer drugs in human medicine, usually thiopental would be the barbiturate of choice for this application these days. Hexobarbital was also marketed as a rapid-acting sleeping medication with short duration (tradenames: Citopan, Evipan and others, usually in 250 mg strength tablets). Hexobarbital is still used in some scientific research.

Further reading

  • Takenoshita R, Toki S (2004). [New aspects of hexobarbital metabolism: stereoselective metabolism, new metabolic pathway via GSH conjugation, and 3-hydroxyhexobarbital dehydrogenases]. Yakugaku Zasshi 124 (12): 857–71.
  • Wahlström G (1998). A study of the duration of acute tolerance induced with hexobarbital in male rats.. Pharmacol Biochem Behav 59 (4): 945–8.
  • Korkmaz S, Ljungblad E, Wahlström G (1995). Interaction between flumazenil and the anesthetic effects of hexobarbital in the rat.. Brain Res 676 (2): 371–7.
  • Dall V, Orntoft U, Schmidt A, Nordholm L (1993). Interaction of the competitive AMPA receptor antagonist NBQX with hexobarbital.. Pharmacol Biochem Behav 46 (1): 73–6.

Barbiturates edit

Allobarbital, Amobarbital, Aprobarbital, Barbexaclone, Barbital, Butabarbital, Butalbital, Butobarbital, Cyclobarbital, Ethallobarbital, Heptabarbital, Hexobarbital, Mephobarbital, Metharbital, Methohexital, Methylphenobarbital, Pentobarbital, Phenobarbital, Primidone, Proxibarbal, Reposal, Secobarbital, Talbutal, Thiobarbital, Thiopental, Vinbarbital, Vinylbital