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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
Homatropine chemical structure | |
(N,N-dimethyl-8-azoniabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenyl-acetate bromide IUPAC name | |
CAS number 80-49-9 |
ATC code A02BX03 . |
PubChem 6646 |
DrugBank APRD01017 |
Chemical formula | {{{chemical_formula}}} |
Molecular weight | 356.26 g/mol |
Bioavailability | |
Metabolism | |
Elimination half-life | |
Excretion | {{{excretion}}} |
Pregnancy category | |
Legal status | |
Routes of administration |
- Main article: Alkoloids
Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic, to temporarily paralyze accommodation, and as a mydriatic, to dilate the pupil.
Homatropine is less potent than atropine and has a shorter duration of action. It is available as the hydrobromide or methylbromide salt. The latter, in addition to papaverine, is used as component of mild drugs that help "flush" the bile (e.g. Neo-Bilagit).
Certain preparations of drugs such as hydrocodone are mixed with a small, sub-therapeutic amount homatropine methylbromide to discourage intentional overdose. [1]
Homatropine is also given as an atropine substitute given to reverse the muscarinic and CNS effects associated with indirect cholinomimetic (anti-AChase) administration.
Side effects[]
- Blurred vision
- Sensitivity to light
Contraindications[]
- Untreated glaucoma
- Myasthenia gravis
- Severe heart failure
- Thyrotoxicosis
References[]
Ophthalmologicals: mydriatics and cycloplegics (S01F) | |
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Anticholinergics/antimuscarinics |
Atropine - Scopolamine - Methylscopolamine - Cyclopentolate - Homatropine - Tropicamide |
Sympathomimetics |
Phenylephrine - Ephedrine - Ibopamine |
Template:Eye navs |
Cholinergics | ||||||||||||||||||
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