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in: Endocrinology of depression, HPA axis

Hypothalamus-pituitary-adrenal theory of depression

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In the endocrinology of depression, the hypothalamic-pituitary-adrenal axis is a chain of endocrine structures that are activated during the body's response to stressors of various sorts. It often shows increased activation in depressed people, but the mechanism behind this is not yet known.[1]


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  1. ↑ Pariante CM, Lightman SL. (September 2008). The HPA axis in major depression: classical theories and new developments.. Trends Neurosci. 31 (9): :464–468. DOI: 10.1016/j.tins.2008.06.006.
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