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Lateral horn
A spinal nerve with its anterior and posterior roots. (Lateral column labeled at top.)
Latin cornu laterale medullae spinalis
Gray's subject #185 753
MeSH [1]
Transverse section of the medulla spinalis in the mid-thoracic region. (Lateral column labeled at center right.)

In the thoracic region, the postero-lateral part of the anterior column projects lateralward as a triangular field, which is named the lateral column (lateral cornu, lateral horn).

Nerve Cells in the Lateral Column

These form a column (the intermedioloateral cell column) which is best marked where the lateral gray column is differentiated, viz., in the thoracic region; but it can be traced throughout the entire length of the medulla spinalis in the form of groups of small cells which are situated in the anterior part of the formatio reticularis. The intermediolateral cell column exists at vertebral levels T1 - L3 and mediates the entire sympathetic innervation of the body. Preganglionic, myelinated GVA fibers from viscera course through prevertebral and paravertebral (sympathetic) ganglia, white rami and dorsal roots to synapse with cells of the intermediolateral cell column. These cells then give rise to preganglionic GVE fibers which will pass through ventral spinal roots, white rami, and into paravertebral ganglia where some will synapse, thus sending unmyelinated, postganglionic fibers through gray rami and into peripheral nerves. Those fibers that do not synapse in the paravertebral ganglia will eventually synapse at prevertebral ganglia near target viscera. Postganglionic neurons in the prevertebral ganglia send postganglionic fibers to target tissues.

In the upper part of the cervical region and lower part of the medulla oblongata as well as in the third and fourth sacral segments this column is again differentiated.

In the medulla it is known as the lateral nucleus.

The cells of this column are fusiform or star-shaped, and of a medium size: the axons of some of them pass into the anterior nerve roots, by which they are carried to the sympathetic nerves: they constitute the white rami and are sympathetic or visceral efferent fibers; they are also known as preganglionic fibers of the sympathetic system; the axons of others pass into the anterior and lateral funiculi, where they become longitudinal.

This article was originally based on an entry from a public domain edition of Gray's Anatomy. As such, some of the information contained herein may be outdated. Please edit the article if this is the case, and feel free to remove this notice when it is no longer relevant.

Spinal cord

epidural space, dura mater, subdural space, arachnoid mater, subarachnoid space, pia mater, denticulate ligaments, conus medullaris, cauda equina, filum terminale, cervical enlargement, lumbar enlargement, anterior median fissure, dorsal root, dorsal root ganglion, dorsal ramus, ventral root, ventral ramus, sympathetic trunk, gray ramus communicans, white ramus communicans

grey matter: central canal, substantia gelatinosa of Rolando, reticular formation, substantia gelatinosa centralis, interneuron, anterior horn, lateral horn, posterior horn (column of Clarke, dorsal spinocerebellar tract)

white matter: anterior funiculus: descending (anterior corticospinal tract, vestibulospinal fasciculus, tectospinal tract), ascending (anterior spinothalamic tract, anterior proper fasciculus)

lateral funiculus: descending (lateral corticospinal tract, rubrospinal tract, olivospinal tract), ascending dorsal spinocerebellar tract, ventral spinocerebellar tract, spinothalamic tract, lateral spinothalamic tract, anterior spinothalamic tract, spinotectal tract, posterolateral tract, lateral proper fasciculus, medial longitudinal fasciculus

posterior funiculus: fasciculus gracilis, fasciculus cuneatus, posterior proper fasciculus

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