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Lofepramine chemical structure
|ATC code |
|Molecular weight||418.958 g/mol|
|Routes of administration||Oral|
Lofepramine (trademarked Gamanil) is a third generation tricyclic antidepressant used in the treatment of depressive disorders. It has both antidepressant and anxiolytic properties. Lofepramine is metabolized in vivo into desipramine; hence its pharmacological profile is extremely similar.
In the United Kingdom, lofepramine is licensed for the treatment of depression.
In the United Kingdom, lofepramine is marketed generically (as the hydrochloride salt) in the form of 70mg tablets.
140-210mg daily in divided doses.
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