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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
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Lofepramine chemical structure | |
IUPAC name | |
| CAS number [1] |
ATC code [[ATC_code_|]][2] |
| PubChem 3947 |
DrugBank [3] |
| Chemical formula | {{{chemical_formula}}} |
| Molecular weight | 418.958 g/mol |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Pregnancy category | |
| Legal status | |
| Routes of administration | Oral |
Lofepramine (trademarked Gamanil) is a third generation tricyclic antidepressant used in the treatment of depressive disorders. It has both antidepressant and anxiolytic properties. Lofepramine is metabolized in vivo into desipramine; hence its pharmacological profile is extremely similar.
Indications[]
In the United Kingdom, lofepramine is licensed for the treatment of depression.
Availability[]
In the United Kingdom, lofepramine is marketed generically (as the hydrochloride salt) in the form of 70mg tablets.
Dosage[]
140-210mg daily in divided doses.
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