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Marcus E. Raichle is an American neurologist at the Washington University School of Medicine in Saint Louis, Missouri. He is a professor in the Department of Radiology with joint appointments in Neurology, Neurobiology and Biomedical Engineering. His research over the past 40 years has focused on the nature of functional brain imaging signals arising from PET and fMRI and the application of these techniques to the study of the human brain in health and disease.
Noteworthy accomplishments during this time have been the discovery of the relative independence of blood flow and oxygen consumption during changes in brain activity which provided the physiological basis of fMRI; the discovery of a default mode of brain function (i.e., organized intrinsic activity) and its signature system, the brain’s default mode network; and, the discovery that aerobic glycolysis contributes to brain function independent of oxidative phosphorylation.
- Zhang, D, Snyder AZ, Shimony JS, Fox MD, Raichle ME (2010). Noninvasive functional and structural connectivity mapping of the human thalamocortical system. Cerebral Cortex 20 (5): 1187–1194.
- Fair, DA, Bathula D, Mills KL, Costa Dias TG, Blythe MS, Zhang D, Snyder AZ, Raichle ME, Stevens AA, Nigg JT, Nagel BJ (2010). thalamocortical functional connectivity across development. Frontiers in Systems Neuroscience 4: 1–10.
- He, BJ, Zempel JM, Snyder AZ, Raichle ME (2010). The temporal structures and functional significance of scale-free brain activity. Neuron 66 (3): 353–369.
- Raichle, ME (2010). Two views of brain function. Trends in Cognitive Science 14 (4): 180–190.
- Raichle, ME (2010). The brain's dark energy. Scientific American 302 (3): 28–33.
- Paul, BM, Snyder AZ, Haist F, Raichle ME, Bellugi U, Stiles J (2009). Amygdala response to faces parallels social behavior in Williams syndrome. Social Cognitive and Affective Neuroscience 4 (3): 278–285.
- Zhang, D, Raichle ME (2010). Disease and the brain's dark energy. Nature Reviews Neurology 6 (1): 15–28.
- Sheline, YI, Raichle ME, Snyder AZ, Morris JC, Head D, Wang S. Mintun MA (2010). Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly. J. Biological Psychiatry 67 (6): 584–587.
- Raichle, ME (2009). A paradigm shift in functional brain imaging. J. Neuroscience 29 (41): 12729–12734.
- White, BR, Snyder AZ, Cohen AL, Petersen SE, Raichle ME, Schlaggar BL, Culver JP (2009). Resting-state functional connectivity in the human brain revealed with diffuse optical tomography. NeuroImage 47 (1): 148–156.
- He, BJ, Raichle ME (2009). The fMRI signal, slow cortical potentials and consciousness. Trends in Cognitive Science 13 (7): 302–309.
- Member: National Academy of Sciences, Institute of Medicine, American Academy of Arts and Sciences.
- Fellow: American Association Advancement of Science.
- Society for Neuroscience
- American Neurological Association
- American Academy Neurology
- International Society Cerebral Blood Flow & Metabolism.
- Academy Members.
- Petersen, SE, Fox PT, Posner MI, Mintun M, Raichle ME (1988). Positron emission tomographic studies of the cortical anatomy of single-word processing. Nature 331 (6157): 585–589.
- Fox, MD, Zhang D, Snyder DZ, Raichle ME (2009). The global signal and observed anticorrelated resting state brain networks. J. Neurophysiology 101 (6): 3270–3283.
- Vlassenko, AG, Vaishnavi SN, Couture L, Sacco D, Shannon BJ, Mac, RH, Morris JC, Raichle ME, Mintun MA (2010). Spatial correlation between brain aerobic glycolysis and amyloid-β deposition. PNAS 107 (41): 17763–17767.