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Brain: Medial forebrain bundle
Latin fasciculus medialis telencephali
Gray's subject #
Part of
BrainInfo/UW hier-416
MeSH [1]

The Medial forebrain bundle (MFB) is a pathway in the limbic system,a complex bundle of axons coming from the precommissural fornix and basal olfactory bulb regions, the periamygdaloid region, and the septal nuclei.


It passes to the lateral hypothalamus, with some carrying on into the tegmentum. It contains both ascending and descending fibers. It also represents a part of the mesolimbic pathway, carrying information between the ventral tegmentum and the nucleus accumbens.

Role in brian stimulation reward

It is commonly accepted that the MFB is involved in the integration of reward and pleasure.

Electrical stimulation of the medial forebrain bundle is believed to cause sensations of pleasure. This hypothesis is based upon intracranial self-stimulation (ICSS) studies. Animals will work for MFB ICSS, and humans report that MFB ICSS is intensely pleasurable. This is most likely because the medial forebrain bundle carries information ventral tegmental area (VTA) to the nucleus accumbens (nAcc or Acb). The nAcc is a recognized reward center, and activation of the pathway from the VTA to the nAcc is believed to be rewarding.

See also

External links

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