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Brain: Medial globus pallidus
Brain structure.gif
Globus pallidus labeled at bottom right.
DA-loops in PD
Latin Globus pallidus medialis,
globus pallidus internus
Gray's subject #
Part of
BrainInfo/UW hier-215
MeSH [1]

The medial globus pallidus (or internal, GPi) is one of the output nuclei of the basal ganglia (the other being the substantia nigra pars reticulata). The GABA-containing neurons send their axons to specific nuclei of the dorsal thalamus (VA and VL), to the centromedian complex and to the pedunculopontine complex.[1][2]

The efferent bundle is constituted first of the ansa and fasciculus lenticularis, then crosses the internal capsule as the Edinger's comb system then arrives at the laterosuperior corner of the subthalamic nucleus and constitutes the Forel's field H2, then H, and suddenly changes its direction to form H1 that goes to the inferior part of the thalamus. The distribution of axonal islands is widespread in the lateral region of the thalamus. The innervation of the central region is done by collaterals.[3]

See also


  1. Nauta WJ, Mehler WR (January 1966). Projections of the lentiform nucleus in the monkey. Brain Res. 1 (1): 3–42.
  2. Percheron G, François C, Talbi B, Meder JF, Fenelon G, Yelnik J (1993). The primate motor thalamus analysed with reference to subcortical afferent territories. Stereotact Funct Neurosurg 60 (1–3): 32–41.
  3. Yelnik J, François C, Percheron G, Tandé D (April 1996). A spatial and quantitative study of the striatopallidal connection in the monkey. Neuroreport 7 (5): 985–988.



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