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Brain: Median raphe nucleus
Latin nucleus raphes medianus, nucleus centralis superior
Gray's subject #
Part of
BrainInfo/UW hier-557
MeSH [1]

The median raphe nucleus (or superior central nucleus) is composed of polygonal, fusiform and pyriform neurons and exists rostral to the nucleus raphe pontis.

One trait of the NCS is its inhibition by lysergic acid diethylamide and psilocin, two serotonin antagonist hallucinogens. The inactivation of the nucleus centralis superior via LSD produces a dose dependent inactivation in the NCS, but not in the raphe pallidus.

The free-moving cats, in which this was discovered, exhibited dose dependent behavioral changes when researched by Dr. Michael Trulson of the neurology department at Texas A&M University Medical School. [1].

See also


  1. Trulson, M.E., Preussler DW and Trulson V.M. Differential effects of hallucinogenic drugs on the activity of serotonin-containing neurons in the nucleus centralis superior and nucleus raphe pallidus in free-moving cats. American Society for Pharmacology and Experimental Therapeutics Volume 228, Issue 1, pp. 94-102, 01/01/1984

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