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melatonin receptor 1A
Symbol(s): MTNR1A
Locus: 4 q35.1
EC number [1]
EntrezGene 4543
OMIM 600665
RefSeq NM_005958
UniProt P48039
melatonin receptor 1B
Symbol(s): MTNR1B
Locus: 11 q21 -q22
EC number [2]
EntrezGene 4544
OMIM 600804
RefSeq NM_005959
UniProt P49286

A melatonin receptor is a G protein-coupled receptor (GPCR) which binds melatonin.[1]

Three types of melatonin receptor have been cloned. The MT1 (or Mel1a or MTNR1A) and MT2 (or Mel1b or MTNR1B) receptor subtypes are present in humans and other mammals[2], while an additional melatonin receptor subtype Mel1c has been identified in amphibia and birds.[3]

Expression patterns

In mammals, melatonin receptors are found in the brain and some peripheral organs. However, there is considerable variation in the density and location of the expression of melatonin receptors between species.[4] The MT1 subtype is present in the pars tuberalis of the pituitary gland and the suprachiasmatic nuclei of the hypothalamus. The MT2 subtype is mainly present in the retina. The Mel1c type receptor of many lower vertebrates is expressed in many brain areas.[3]

See also


  1. Reppert SM (1997). Melatonin receptors: molecular biology of a new family of G protein-coupled receptors. J. Biol. Rhythms 12 (6): 528–31.
  2. Reppert SM, Weaver DR, Godson C (1996). Melatonin receptors step into the light: cloning and classification of subtypes. Trends Pharmacol. Sci. 17 (3): 100–2.
  3. 3.0 3.1 Sugden D, Davidson K, Hough KA, Teh MT (2004). Melatonin, melatonin receptors and melanophores: a moving story. Pigment Cell Res. 17 (5): 454–60.
  4. Morgan PJ, Barrett P, Howell HE, Helliwell R (1994). Melatonin receptors: localization, molecular pharmacology and physiological significance. Neurochem. Int. 24 (2): 101–46.

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