Melatonin receptor 1A

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Melatonin receptor 1A

Identifiers

Symbol(s)

MTNR1A; MT1; MEL-1A-R

External IDs

OMIM: 600665 MGI: 102967 Homologene: 21207

Gene Ontology Molecular Function: • receptor activity • melatonin receptor activity Cellular Component: • integral to plasma membrane • membrane Biological Process: • signal transduction • G-protein signaling, coupled to cyclic nucleotide second messenger • mating behavior • circadian rhythm

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Entrez

4543

17773

Ensembl

ENSG00000168412

ENSMUSG00000054764

Uniprot

P48039

Q14AC3

Refseq

NM_005958 (mRNA) NP_005949 (protein)

XM_991330 (mRNA) XP_996424 (protein)

Location

Chr 4: 187.69 - 187.71 Mb

Chr 8: 46.57 - 46.59 Mb

Pubmed search

[1]

[2]

Melatonin receptor 1A, also known as MTNR1A, is a human gene.

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.

See also

• Melatonin receptor

Further reading

• Brzezinski A (1997). Melatonin in humans.. N. Engl. J. Med. 336 (3): 186-95.
• Khan AU, Olson DL (1975). Physical therapy and exercise-induced bronchospasm.. Physical therapy 55 (8): 878-81.
• Slaugenhaupt SA, Roca AL, Liebert CB, et al. (1995). Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a).. Genomics 27 (2): 355-7.
• Reppert SM, Weaver DR, Ebisawa T (1994). Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses.. Neuron 13 (5): 1177-85.
• Witt-Enderby PA, Dubocovich ML (1996). Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells.. Mol. Pharmacol. 50 (1): 166-74.
• Witt-Enderby PA, Masana MI, Dubocovich ML (1998). Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor.. Endocrinology 139 (7): 3064-71.
• Ebisawa T, Kajimura N, Uchiyama M, et al. (1999). Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders.. Biochem. Biophys. Res. Commun. 262 (3): 832-7.
• Brydon L, Roka F, Petit L, et al. (2000). Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins.. Mol. Endocrinol. 13 (12): 2025-38.
• Niles LP, Wang J, Shen L, et al. (2000). Melatonin receptor mRNA expression in human granulosa cells.. Mol. Cell. Endocrinol. 156 (1-2): 107-10.
• Song CK, Bartness TJ (2001). CNS sympathetic outflow neurons to white fat that express MEL receptors may mediate seasonal adiposity.. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 (2): R666-72.
• Roy D, Angelini NL, Fujieda H, et al. (2001). Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin.. Endocrinology 142 (11): 4711-20.
• Savaskan E, Olivieri G, Meier F, et al. (2002). Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients.. J. Pineal Res. 32 (1): 59-62.
• Savaskan E, Wirz-Justice A, Olivieri G, et al. (2002). Distribution of melatonin MT1 receptor immunoreactivity in human retina.. J. Histochem. Cytochem. 50 (4): 519-26.
• Ayoub MA, Couturier C, Lucas-Meunier E, et al. (2002). Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer.. J. Biol. Chem. 277 (24): 21522-8.
• Yuan L, Collins AR, Dai J, et al. (2003). MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells.. Mol. Cell. Endocrinol. 192 (1-2): 147-56.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903.
• Slominski A, Pisarchik A, Zbytek B, et al. (2003). Functional activity of serotoninergic and melatoninergic systems expressed in the skin.. J. Cell. Physiol. 196 (1): 144-53.
• Morcuende JA, Minhas R, Dolan L, et al. (2004). Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis.. Spine 28 (17): 2025-8; discussion 2029.
• Aust S, Thalhammer T, Humpeler S, et al. (2004). The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia.. J. Pineal Res. 36 (1): 43-8.