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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
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Melperone chemical structure | |
| 1-(4-fluorophenyl)-4-(4-methyl-1-piperidyl)butan-1-one IUPAC name | |
| CAS number 3575-80-2 |
ATC code |
| PubChem 15387 |
DrugBank [1] |
| Chemical formula | {{{chemical_formula}}} |
| Molecular weight | 263.35 g/mol |
| Bioavailability | |
| Metabolism | Hepatic (inhibits CYP2D6[1]) |
| Elimination half-life | 3–4 hours (oral) 6 hours (IM) |
| Excretion | |
| Pregnancy category | |
| Legal status | |
| Routes of administration | Oral, intramuscular injection |
Melperone (INN, also known as methylperone) is a butyrophenone atypical antipsychotic. It is sold under the trade names Buronil, Burnil, and Eunerpan.
Chemistry[]
- Molecular Formula: C16H23ClFNO
- Molecular Weight: 299.82
- Chemical Class: Butyrophenone
- Pharmacological Class: Atypical antipsychotic
- Appearance: White, crystalline odorless powder
- Solubility: Free soluble in water. Freely soluble in ethanol 99.5% and chloroform. Practically insoluble in diethyl ether.
- Melting Point: 205-210C
- pH (1% in water): 4.5-6.5
- Stability: 48 months
It is a white crystalline powder that is manufactured by Dupont Chemoswed (Sweden). It is a butyrophenone (1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone hydrochloride).
References[]
- ↑ Grözinger M, Dragicevic A, Hiemke C, Shams M, Müller MJ, Härtter S (2003). Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine. Pharmacopsychiatry 36 (1): 3–6.
External links[]
Psycholeptics: antipsychotics (N05A)
| |
|---|---|
| Phenothiazine typical antipsychotics | Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine |
| Other typical antipsychotics | Indoles (Molindone) • Butyrophenones (Azaperone, Benperidol, Droperidol, Haloperidol) • Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) • diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) • other (Loxapine) |
| Atypical antipsychotics | Butyrophenones (Melperone) • Indoles (Sertindole, Ziprasidone) • Benzamides (Sulpiride, Remoxipride, Amisulpride) • diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) • other (Aripiprazole, Risperidone, Paliperidone, Zotepine) |
- de:Melperon
- sv:Melperon
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