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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
|
Methysergide chemical structure | |
| 1-Methyl-d-lysergic acid-(1-hydroxybut-2-yl)amide IUPAC name | |
| CAS number 361-37-5 |
ATC code |
| PubChem 9681 |
DrugBank APRD00463 |
| Chemical formula | {{{chemical_formula}}} |
| Molecular weight | 353.458 g/mol |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | {{{excretion}}} |
| Pregnancy category | X |
| Legal status | |
| Routes of administration | |
- Main article: Serotonin antagonists
Methysergide (UML-491) is a prescription drug used for prophylaxis of migraine headaches and is sold under the brand names Sansert and Deseril in 2mg dosages.
Pharmacology[]
It is a receptor antagonist for the 5-HT receptor 2C[1]. It also is a 5-HT1A receptor antagonist.[2]
It is known to have partial agonists effects on 5-HT receptors as well.[3]
Uses[]
Methysergide is one of the most effective[4] medications for the prevention of migraine, but not for the treatment of an acute attack.
Side effects[]
It has a known side effect, retroperitoneal fibrosis[5], which is severe, although uncommon.
In addition, there is an increased risk of left-sided cardiac valve dysfunction.[4][6]
History[]
Methysergide was approved by the FDA in 1962.
Novartis withdrew it from the U.S. market after taking over Sandoz, but currently lists it as a product.
Related compounds[]
Its molecular structure is closely related to that of LSD.
Like LSD, methysergide also produces psychedelic and hallucinogenic effects above a dosage of about 4mg.[7] Full effects are felt with dosages of 8-20mg.[How to reference and link to summary or text]
About 4 mg is equal to 25mcg of LSD.[8]
See also[]
Triptan
References[]
- ↑ Rang, H. P. (2003). Pharmacology, Edinburgh: Churchill Livingstone. Page 187
- ↑ Saxena PR, Lawang A (October 1985). A comparison of cardiovascular and smooth muscle effects of 5-hydroxytryptamine and 5-carboxamidotryptamine, a selective agonist of 5-HT1 receptors. Arch Int Pharmacodyn Ther 277 (2): 235–52.
- ↑ Colpaert FC, Niemegeers CJ, Janssen PA (October 1979). In vivo evidence of partial agonist activity exerted by purported 5-hydroxytryptamine antagonists. Eur. J. Pharmacol. 58 (4): 505–9.
- ↑ 4.0 4.1 Joseph T, Tam SK, Kamat BR, Mangion JR (2003). Successful repair of aortic and mitral incompetence induced by methylsergide maleate: confirmation by intraoperative transesophageal echocardiography. Echocardiography 20 (3): 283–7.
- ↑ emedicine.com (2002)
- ↑ 1997 Mayo Clinic study linking heart disease to Fen Phen Valvular heart disease associated with fenfluramine-phentermine
- ↑ L. Bender (1970): "Children's Reactions to Psychotomimetic Drugs", Psychotomimetic Drugs, pp. 265-273]
- ↑ Abramson HA, Rolo A (September 1965). Lysergic acid diethylamide (LSD-25). 38. Comparison with action of methysergide and psilocybin on test subjects. J Asthma Res 3 (1): 81–96.
External links[]
- Novartis Sansert site.
- Novartis Sansert product description.
- Migraines.org More detailed information on methysergide.
- neurologychannel.com, general information on migraines.
Template:Serotonin antagonists
Ergolines
| |
|---|---|
| Lysergic acid derivatives | Bromocriptine, Cabergoline, Ergine,Ergonovine, Ergotamine, Lysergic acid, Lysergol, LSD, D-Lysergic acid hydroxyethylamide, Lisuride, Methergine, Methysergide, Pergolide |
| Hallucinogenic lysergamides | AL-LAD, ALD-52, BU-LAD, CYP-LAD, DAL, DAM-57, Ergonovine, ETH-LAD, LAE-32, LSD, LPD-824, LSM-775, D-Lysergic acid N-(α-hydroxyethyl)amide, Methylergonovine, MLD-41, PARGY-LAD, PRO-LAD |
| Other ergolines | Ergoline |
| Natural sources | Argyreia nervosa,
Claviceps spp., Ipomoea tricolor, Ipomoea violacea, Rivea corymbosa |
Template:Antimigraine preparations
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