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Metirosine chemical structure | |
| (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid IUPAC name | |
| CAS number 672-87-7 |
ATC code C02KB01 |
| PubChem 10123 |
DrugBank [1] |
| Chemical formula | {{{chemical_formula}}} |
| Molecular weight | 195.215 g/mol |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | 3.4–3.7 hours |
| Excretion | {{{excretion}}} |
| Pregnancy category | |
| Legal status | |
| Routes of administration | |
Metirosine (α-Methyltyrosine, Metyrosine, AMPT) is an antihypertensive drug. It inhibits the enzyme tyrosine hydroxylase and, therefore, catecholamine synthesis, which consequently depletes the levels of the catecholamines dopamine, adrenaline and noradrenaline in the body.
Clinical use[]
Metirosine has been used in the treatment of phaeochromocytoma.[1] It is contra-indicated for the treatment of essential hypertension.
However it is now rarely used in medicine, and its main use is in scientific research, to investigate the effects of catecholamine depletion on behaviour.[2]
See also[]
References[]
- ↑ Green KN, Larsson SK, Beevers DG, Bevan PG, Hayes B (August 1982). Alpha-methyltyrosine in the management of phaeochromocytoma. Thorax 37 (8): 632–3.
- ↑ O'Leary OF, Bechtholt AJ, Crowley JJ, Hill TE, Page ME, Lucki I. Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test. Psychopharmacology (Berlin). 2007 Jun;192(3):357-71. PMID 17318507
Template:Antihypertensives and diuretics
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