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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
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Molindone chemical structure | |
| 3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)- 1,5,6,7-tetrahydro-4H-indol-4-one IUPAC name | |
| CAS number 7416-34-4 |
ATC code |
| PubChem 23897 |
DrugBank [1] |
| Chemical formula | {{{chemical_formula}}} |
| Molecular weight | 276.374 g/mol |
| Bioavailability | |
| Metabolism | Hepatic |
| Elimination half-life | 1.5 hours |
| Excretion | Minor, renal and fecal |
| Pregnancy category | |
| Legal status | |
| Routes of administration | Oral |
Molindone is a therapeutic antipsychotic, used in the treatment of schizophrenia.[1] It works by blocking the effects of dopamine in the brain, leading to diminished psychoses. It is rapidly absorbed when taken by mouth.
Molindone is sold under the product name Moban.
Adverse effects[]
- Main article: Typical antipsychotic
The side effect profile of molindone is similar to that of other typical antipsychotics. Unlike most antipsychotics, however, molindone use is associated with weight loss.[2][3]
See also[]
References[]
- ↑ molindone. (web) F.A. Davis Company. URL accessed on 2007-11-04.
- ↑ Bagnall A, Fenton M, Kleijnen J, Lewis R (2007). Molindone for schizophrenia and severe mental illness. Cochrane Database Syst Rev (1): CD002083.
- ↑ Allison DB, Mentore JL, Heo M, et al (1999). Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry 156 (11): 1686–96. Free full text
Psycholeptics: antipsychotics (N05A)
| |
|---|---|
| Phenothiazine typical antipsychotics | Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine |
| Other typical antipsychotics | Indoles (Molindone) • Butyrophenones (Azaperone, Benperidol, Droperidol, Haloperidol) • Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) • diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) • other (Loxapine) |
| Atypical antipsychotics | Butyrophenones (Melperone) • Indoles (Sertindole, Ziprasidone) • Benzamides (Sulpiride, Remoxipride, Amisulpride) • diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) • other (Aripiprazole, Risperidone, Paliperidone, Zotepine) |
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