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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
Motilin receptor
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| Identifiers | ||||||||||||||||||||||
| Symbol(s) | MLNR; GPR38; MTLR1 | |||||||||||||||||||||
| External IDs | OMIM: 602885 Homologene: 74398 | |||||||||||||||||||||
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| RNA expression pattern | ||||||||||||||||||||||
| Orthologs | ||||||||||||||||||||||
| Human | Mouse | Entrez | 2862 | na | Ensembl | ENSG00000102539 | na | Uniprot | O43193 | na | Refseq | NM_001507 (mRNA) NP_001498 (protein) |
na (mRNA) na (protein) |
Location | Chr 13: 48.69 - 48.69 Mb | na | ||||||
| Pubmed search | [1] | na | ||||||||||||||||||||
Motilin receptor is a G protein-coupled receptor which binds motilin.[1][2] Motilin in turn is an intestinal peptide that stimulates contraction of gut smooth muscle.
References[]
- ↑ Depoortere I (2001). Motilin and motilin receptors: characterization and functional significance. Verh. K. Acad. Geneeskd. Belg. 63 (6): 511–29.
- ↑ Yang X, Dong L, Yang H (2006). [Evidence for the presence of motilin receptor and a study on the mechanism of motilin induced Ca2+ signaling in rat myenteric neurons]. Sichuan Da Xue Xue Bao Yi Xue Ban 37 (5): 683–6.
Further reading[]
- Smith RG, Leonard R, Bailey AR, et al. (2001). Growth hormone secretagogue receptor family members and ligands.. Endocrine 14 (1): 9-14.
- McKee KK, Tan CP, Palyha OC, et al. (1998). Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors.. Genomics 46 (3): 426-34.
- Feighner SD, Tan CP, McKee KK, et al. (1999). Receptor for motilin identified in the human gastrointestinal system.. Science 284 (5423): 2184-8.
- Miller P, Roy A, St-Pierre S, et al. (2000). Motilin receptors in the human antrum.. Am. J. Physiol. Gastrointest. Liver Physiol. 278 (1): G18-23.
- Thielemans L, Depoortere I, Van Assche G, et al. (2001). Demonstration of a functional motilin receptor in TE671 cells from human cerebellum.. Brain Res. 895 (1-2): 119-28.
- Coulie B, Matsuura B, Dong M, et al. (2001). Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling.. J. Biol. Chem. 276 (38): 35518-22.
- Thielemans L, Depoortere I, Vanden Broeck J, Peeters TL (2002). The motilin pharmacophore in CHO cells expressing the human motilin receptor.. Biochem. Biophys. Res. Commun. 293 (4): 1223-7.
- Depoortere I, Thijs T, Thielemans L, et al. (2003). Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide-6 with the motilin receptor in the rabbit gastric antrum.. J. Pharmacol. Exp. Ther. 305 (2): 660-7.
- Dunham A, Matthews LH, Burton J, et al. (2004). The DNA sequence and analysis of human chromosome 13.. Nature 428 (6982): 522-8.
- Matsuura B, Dong M, Naik S, et al. (2006). Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity.. J. Biol. Chem. 281 (18): 12390-6.
External links[]
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