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Myalgia of the biceps brachii.jpg|
ICD-10 M791
ICD-9 729.1
OMIM [1]
DiseasesDB 22895
MedlinePlus [2]
eMedicine /
MeSH {{{MeshNumber}}}

Myalgia means "muscle pain" and is a symptom of many diseases and disorders. The most common causes are the overuse or over-stretching of a muscle or group of muscles. Myalgia without a traumatic history is often due to viral infections. Longer-term myalgias may be indicative of a metabolic myopathy, some nutritional deficiencies or chronic fatigue syndrome.


The most common causes of myalgia are overuse, injury or strain. However, myalgia can also be caused by diseases, disorders, medications, or as a response to a vaccination. It is also a sign of acute rejection after heart transplant surgery.

The most common causes are:

  • Injury or trauma, including sprains, hematoma
  • Overuse: using a muscle too much, too often, including protecting a separate injury
  • Chronic tension

Muscle pain occurs with:

  • Rhabdomyolysis, associated with:
    • Viral
    • Compression injury
    • Drug-related, esp fibrates and statins, occ ACE inhibitors, cocaine, some retro-viral drugs
    • Severe potassium deficiency
  • Fibromyalgia
  • Infections, including:
  • Auto-immune disorders, including
  • Systemic lupus erythematosus
  • Polymyalgia rheumatica
  • Polymyositis
  • Dermatomyositis
  • Multiple Sclerosis (this is neurologic pain localised to myotome)


Overuse of a muscle is using it too much, too soon and/or too often.[1] Examples are:


The most common causes of myalgia by injury are: sprains and strain (injury).[1]


Multiple sclerosis(neurologic pain interpreted as muscular), Myalgic Encephalomyelitis, Myositis, Lupus erythematosus, Familial Mediterranean fever, Polyarteritis nodosa, Devic's disease, Morphea

Metabolic defect

Carnitine palmitoyltransferase II deficiency, Conn's syndrome, Adrenal insufficiency, Hyperthyroidism, Hypothyroidism


Chronic fatigue syndrome, Ehlers Danlos Syndrome, Hypokalemia, Exercise intolerance, Mastocytosis, Peripheral neuropathy, Eosinophilia myalgia syndrome, Fibromyalgia, Barcoo Fever, Herpes, Delayed onset muscle soreness, AIDS, HIV, Tumor-induced osteomalacia, Post Orgasmic Illness Syndrome


Acrylamide, Aspirin, colesevelam, darbepoetin, darunavir, daptomycin, ezetimibe, ibandronate sodium, ibuprofen, imiquimod, interferons, isotretinoin, procainamide, quinupristin/dalfopristin, statins, sumatriptan, tasigna, tiotropium, vardenafil, zolmitriptan, zocor.

Withdrawal syndromes

Sudden cessation of high-dose corticosteroids, opioids, barbiturates, benzodiazepines, or alcohol can induce myalgia.

See also


External links


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