| neuropeptides B/W receptor 1 | |
|---|---|
| Symbol(s): | NPBWR1 GPR7 |
| Locus: | 8 p22-q21.13 |
| EC number | [1] |
| EntrezGene | 2831 |
| OMIM | 600730 |
| RefSeq | NM_005285 |
| UniProt | P48145 |
| neuropeptides B/W receptor 2 | |
|---|---|
| Symbol(s): | NPBWR2 GPR8 |
| Locus: | 20 q13.3 |
| EC number | [2] |
| EntrezGene | 2832 |
| OMIM | 600731 |
| RefSeq | NM_005286 |
| UniProt | P48146 |
The neuropeptide B/W receptors are members of the G-protein coupled receptor superfamily of integral membrane proteins which bind the neuropeptides B and W.[1] These receptors are predominately expressed in the CNS and have a number of functions including regulation of the secretion of cortisol.[2][3]
References[]
- ↑ Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K, Yamanaka A, Williams SC, Richardson JA, Tsujino N, Garry MG, Lerner MR, King DS, O'Dowd BF, Sakurai T, Yanagisawa M (2003). Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6.
- ↑ Mazzocchi G, Rebuffat P, Ziolkowska A, Rossi GP, Malendowicz LK, Nussdorfer GG (2005). G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades. J. Clin. Endocrinol. Metab. 90 (6): 3466–71.
- ↑ Singh G, Davenport AP (2006). Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system. Br. J. Pharmacol. 148 (8): 1033–41.
External links[]
- Neuropeptide W/Neuropeptide B Receptors. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- MeSH NPBWR1+protein,+human
- MeSH GPR8+protein,+human
Neuropeptide receptors | |
|---|---|
| Hypothalamic hormone receptors |
CRH - FSH - LHRH - TRH - Somatostatin |
| Pituitary hormone receptors |
Vasopressin (1A, 1B, 2) - Oxytocin - LHCG - Type I cytokine receptor (GH, Prolactin) - TSH |
| Other hormone receptors |
Atrial natriuretic factor - Calcitonin - Cholecystokinin - VIP |
| Opioid receptors |
Delta - Kappa - Mu - Sigma (1, 2) - Nociceptin |
| Other neuropeptide receptors |
Angiotensin - Bradykinin/Tachykinin (TACR1) - Calcitonin gene-related peptide - Galanin - GPCR neuropeptide (B/W, FF, S, Y) - Neurotensin |
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