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neuropeptides B/W receptor 1
Symbol(s): NPBWR1 GPR7
Locus: 8 p22-q21.13
EC number [1]
EntrezGene 2831
OMIM 600730
RefSeq NM_005285
UniProt P48145
neuropeptides B/W receptor 2
Symbol(s): NPBWR2 GPR8
Locus: 20 q13.3
EC number [2]
EntrezGene 2832
OMIM 600731
RefSeq NM_005286
UniProt P48146

The neuropeptide B/W receptors are members of the G-protein coupled receptor superfamily of integral membrane proteins which bind the neuropeptides B and W.[1] These receptors are predominately expressed in the CNS and have a number of functions including regulation of the secretion of cortisol.[2][3]


  1. Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K, Yamanaka A, Williams SC, Richardson JA, Tsujino N, Garry MG, Lerner MR, King DS, O'Dowd BF, Sakurai T, Yanagisawa M (2003). Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6.
  2. Mazzocchi G, Rebuffat P, Ziolkowska A, Rossi GP, Malendowicz LK, Nussdorfer GG (2005). G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades. J. Clin. Endocrinol. Metab. 90 (6): 3466–71.
  3. Singh G, Davenport AP (2006). Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system. Br. J. Pharmacol. 148 (8): 1033–41.

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