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neuropeptide FF receptor 1
Symbol(s): NPFFR1 GPR147
Locus: 10 q21-q22
EC number [1]
EntrezGene 64106
OMIM 607448
RefSeq NM_022146
UniProt Q9GZQ6
neuropeptide FF receptor 2
Symbol(s): NPFFR2 GPR74
Locus: 4 q21
EC number [2]
EntrezGene 10886
OMIM 607449
RefSeq NM_004885
UniProt Q9Y5X5

The neuropeptide FF receptors[1] are members of the G-protein coupled receptor superfamily of integral membrane proteins which bind the pain modulatory neuropeptides AF and FF.[2][3]


  1. Parker RM, Copeland NG, Eyre HJ, Liu M, Gilbert DJ, Crawford J, Couzens M, Sutherland GR, Jenkins NA, Herzog H (2000). Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family. Brain Res. Mol. Brain Res. 77 (2): 199–208.
  2. Elshourbagy NA, Ames RS, Fitzgerald LR, Foley JJ, Chambers JK, Szekeres PG, Evans NA, Schmidt DB, Buckley PT, Dytko GM, Murdock PR, Milligan G, Groarke DA, Tan KB, Shabon U, Nuthulaganti P, Wang DY, Wilson S, Bergsma DJ, Sarau HM (2000). Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor. J. Biol. Chem. 275 (34): 25965–71.
  3. Mollereau C, Mazarguil H, Marcus D, Quelven I, Kotani M, Lannoy V, Dumont Y, Quirion R, Detheux M, Parmentier M, Zajac JM (2002). Pharmacological characterization of human NPFF(1) and NPFF(2) receptors expressed in CHO cells by using NPY Y(1) receptor antagonists. Eur. J. Pharmacol. 451 (3): 245–56.

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