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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
A nicotinic antagonist is a type of anticholinergic which inhibits the action at nicotinic acetylcholine receptors. These compounds are mainly used for peripheral muscle paralysis in surgery, but some centrally acting compounds such as mecamylamine and 18-methoxycoronaridine block nicotinic acetylcholine receptors in the brain and can be used for treating drug addiction.
Mechanism | Antagonist | Preferred receptor | Clinical use |
---|---|---|---|
Ganglionic blocking agents | Hexamethonium | Ganglion type | none[1] |
Mecamylamine | Ganglion type | ||
Trimethaphan | Ganglion type | Rarely used for blood pressure decrease during surgery[1] | |
Nondepolarizing neuromuscular blocking agents | Atracurium | Muscle type | muscle relaxant in anaesthesia[1] |
Doxacurium | Muscle type | ||
Mivacurium | Muscle type | ||
Pancuronium | Muscle type | muscle relaxant in anaesthesia[1] | |
Tubocurarine | Muscle type | Rarely used [1] | |
Vecuronium | Muscle type | muscle relaxant in anaesthesia[1] | |
Depolarizing neuromuscular blocking agents | Succinylcholine | Muscle type | |
Centrally acting nicotinic antagonists | 18-Methoxycoronaridine | α3β4 |
References[]
External links[]
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Skeletal muscle relaxants (M03) | |||||||||||||||||
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Peripherally acting (primarily antinicotinic, NMJ block) |
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Centrally acting |
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Directly acting | |||||||||||||||||
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Neuromodulation | |||||||||||||||||||||||||||||||||||||||||
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Types |
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Classes |
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Receptor agonists, antagonists, and reuptake inhibitors | |
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Dopamine receptor |
Dopamine agonist • Dopamine antagonist • Dopamine reuptake inhibitor |
5-HT (serotonin) receptor |
Serotonin receptor agonist • Serotonin antagonist (5-HT3) • Serotonin uptake inhibitor (SSRI) |
Adrenergic receptor |
Adrenergic agonist (Alpha, Beta2) • Adrenergic antagonist (Alpha, Beta) • Adrenergic uptake inhibitor |
Acetylcholine receptor |
Cholinergic (Muscarinic, Nicotinic) • Anticholinergic (Muscarinic, Nicotinic) • Acetylcholinesterase inhibitor |
Histamine receptor |
Histamine agonist • Histamine antagonist (H1, H2) |
GABA receptor | |
NMDA receptor |
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