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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
Oxytocin receptor
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| Identifiers | ||||||||||||||||||||||
| Symbol(s) | OXTR; OT-R | |||||||||||||||||||||
| External IDs | OMIM: 167055 MGI: 109147 Homologene: 20255 | |||||||||||||||||||||
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| RNA expression pattern | ||||||||||||||||||||||
| Orthologs | ||||||||||||||||||||||
| Human | Mouse | Entrez | 5021 | 18430 | Ensembl | ENSG00000180914 | ENSMUSG00000049112 | Uniprot | P30559 | Q3UPP9 | Refseq | NM_000916 (mRNA) NP_000907 (protein) |
XM_001001627 (mRNA) XP_001001627 (protein) |
Location | Chr 3: 8.77 - 8.79 Mb | Chr 6: 112.44 - 112.46 Mb | ||||||
| Pubmed search | [1] | [2] | ||||||||||||||||||||
Oxytocin receptors function as inducers of uterine contractions and milk ejection.[1][2] Oxytocin receptors are expressed by the myoepithelial cells of the mammary gland, and in both the myometrium and endometrium of the uterus at the end of pregnancy. In some mammals, oxytocin receptors are also found in the kidney and heart.
The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition.[3]
References[]
- ↑ Gimpl G, Fahrenholz F (2001). The oxytocin receptor system: structure, function, and regulation. Physiol. Rev. 81 (2): 629–83.
- ↑ Zingg HH, Laporte SA (2003). The oxytocin receptor. Trends Endocrinol. Metab. 14 (5): 222–7.
- ↑ Entrez Gene: OXTR oxytocin receptor.
External links[]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Neuropeptide receptors | |
|---|---|
| Hypothalamic hormone receptors |
CRH - FSH - LHRH - TRH - Somatostatin |
| Pituitary hormone receptors |
Vasopressin (1A, 1B, 2) - Oxytocin - LHCG - Type I cytokine receptor (GH, Prolactin) - TSH |
| Other hormone receptors |
Atrial natriuretic factor - Calcitonin - Cholecystokinin - VIP |
| Opioid receptors |
Delta - Kappa - Mu - Sigma (1, 2) - Nociceptin |
| Other neuropeptide receptors |
Angiotensin - Bradykinin/Tachykinin (TACR1) - Calcitonin gene-related peptide - Galanin - GPCR neuropeptide (B/W, FF, S, Y) - Neurotensin |
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