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| parathyroid hormone receptor 1 | |
|---|---|
| Symbol(s): | PTHR1 PTHR |
| Locus: | 3 p22 -p21.1 |
| EC number | [1] |
| EntrezGene | 5745 |
| OMIM | 168468 |
| RefSeq | NM_000316 |
| UniProt | Q03431 |
| parathyroid hormone receptor 2 | |
|---|---|
| Symbol(s): | PTHR2 |
| Locus: | 2 q33 |
| EC number | [2] |
| EntrezGene | 5746 |
| OMIM | 601469 |
| RefSeq | NM_005048 |
| UniProt | P49190 |
There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors are members of the 7 transmembrane G protein-coupled family of receptors.[1]
- parathyroid hormone receptor 1 (PTH1) is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.[2][3]
- parathyroid hormone receptor 2 (PTH2) is expressed primarily in the central nervous system, pancreas, testis, and placenta.[4]
References[]
- ↑ Jüppner H (1994). Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors. Curr. Opin. Nephrol. Hypertens. 3 (4): 371–8.
- ↑ Mannstadt M, Jüppner H, Gardella TJ (1999). Receptors for PTH and PTHrP: their biological importance and functional properties. Am. J. Physiol. 277 (5 Pt 2): F665–75.
- ↑ Offermanns S, Iida-Klein A, Segre GV, Simon MI (1996). G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells. Mol. Endocrinol. 10 (5): 566–74.
- ↑ Usdin TB, Bonner TI, Hoare SR (2002). The parathyroid hormone 2 (PTH2) receptor. Recept. Channels 8 (3-4): 211–8.
External links[]
- MeSH Parathyroid+Hormone+Receptors
- Parathyroid Hormone Receptors. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
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