Parathyroid hormone receptor 1

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Parathyroid hormone receptor 1 is a parathyroid hormone receptor It is encoded by the gene PTHR1. It is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH).

Function

It is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.

Mechanism

It is a member of the secretin family of G protein-coupled receptors. The activity of this receptor is mediated by G_s G proteins which activate adenylyl cyclase. Besides, they also activate phosphatidylinositol-calcium second messenger system.

Pathology

Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis.

See also

• Parathyroid hormone receptor

Further reading

• Bonaventure J, Silve C (2006). [Hereditary skeletal dysplasias and FGFR3 and PTHR1 signaling pathways]. Med Sci (Paris) 21 (11): 954–61.
• Dawson SJ, White LA (1992). Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.. J. Infect. 24 (3): 317–20.
• Schipani E, Kruse K, Jüppner H (1995). A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia.. Science 268 (5207): 98–100.
• Schipani E, Weinstein LS, Bergwitz C, et al. (1995). Pseudohypoparathyroidism type Ib is not caused by mutations in the coding exons of the human parathyroid hormone (PTH)/PTH-related peptide receptor gene.. J. Clin. Endocrinol. Metab. 80 (5): 1611–21.
• Pausova Z, Bourdon J, Clayton D, et al. (1994). Cloning of a parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR) cDNA from a rat osteosarcoma (UMR 106) cell line: chromosomal assignment of the gene in the human, mouse, and rat genomes.. Genomics 20 (1): 20–6.
• McCuaig KA, Clarke JC, White JH (1994). Molecular cloning of the gene encoding the mouse parathyroid hormone/parathyroid hormone-related peptide receptor.. Proc. Natl. Acad. Sci. U.S.A. 91 (11): 5051–5.
• Schipani E, Karga H, Karaplis AC, et al. (1993). Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor.. Endocrinology 132 (5): 2157–65.
• Schneider H, Feyen JH, Seuwen K, Movva NR (1993). Cloning and functional expression of a human parathyroid hormone receptor.. Eur. J. Pharmacol. 246 (2): 149–55.
• Schipani E, Langman CB, Parfitt AM, et al. (1996). Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen's metaphyseal chondrodysplasia.. N. Engl. J. Med. 335 (10): 708–14.
• Zhou AT, Bessalle R, Bisello A, et al. (1997). Direct mapping of an agonist-binding domain within the parathyroid hormone/parathyroid hormone-related protein receptor by photoaffinity crosslinking.. Proc. Natl. Acad. Sci. U.S.A. 94 (8): 3644–9.
• Schipani E, Jensen GS, Pincus J, et al. (1997). Constitutive activation of the cyclic adenosine 3',5'-monophosphate signaling pathway by parathyroid hormone (PTH)/PTH-related peptide receptors mutated at the two loci for Jansen's metaphyseal chondrodysplasia.. Mol. Endocrinol. 11 (7): 851–8.
• Jobert AS, Zhang P, Couvineau A, et al. (1998). Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia.. J. Clin. Invest. 102 (1): 34–40.
• Pellegrini M, Bisello A, Rosenblatt M, et al. (1998). Binding domain of human parathyroid hormone receptor: from conformation to function.. Biochemistry 37 (37): 12737–43.
• Zhang P, Jobert AS, Couvineau A, Silve C (1998). A homozygous inactivating mutation in the parathyroid hormone/parathyroid hormone-related peptide receptor causing Blomstrand chondrodysplasia.. J. Clin. Endocrinol. Metab. 83 (9): 3365–8.
• Adams AE, Bisello A, Chorev M, et al. (1999). Arginine 186 in the extracellular N-terminal region of the human parathyroid hormone 1 receptor is essential for contact with position 13 of the hormone.. Mol. Endocrinol. 12 (11): 1673–83.
• Matsuzaki K, Katayama K, Takahashi Y, et al. (1999). Human osteoclast-like cells are formed from peripheral blood mononuclear cells in a coculture with SaOS-2 cells transfected with the parathyroid hormone (PTH)/PTH-related protein receptor gene.. Endocrinology 140 (2): 925–32.
• Schipani E, Langman C, Hunzelman J, et al. (1999). A novel parathyroid hormone (PTH)/PTH-related peptide receptor mutation in Jansen's metaphyseal chondrodysplasia.. J. Clin. Endocrinol. Metab. 84 (9): 3052–7.
• Karperien M, van der Harten HJ, van Schooten R, et al. (1999). A frame-shift mutation in the type I parathyroid hormone (PTH)/PTH-related peptide receptor causing Blomstrand lethal osteochondrodysplasia.. J. Clin. Endocrinol. Metab. 84 (10): 3713–20.
• Watson PH, Fraher LJ, Natale BV, et al. (2000). Nuclear localization of the type 1 parathyroid hormone/parathyroid hormone-related peptide receptor in MC3T3-E1 cells: association with serum-induced cell proliferation.. Bone 26 (3): 221–5.
• Truneh A, Sharma S, Silverman C, et al. (2000). Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor.. J. Biol. Chem. 275 (30): 23319–25.

External links

• Parathyroid Hormone Receptors: PTH1. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• MeSH Receptor,+Parathyroid+Hormone,+Type+1

Template:Transmembranereceptor-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.