Parathyroid hormone receptor 2

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Parathyroid hormone receptor 2

Identifiers

Symbol(s)

PTHR2;

External IDs

OMIM: 601469 MGI: 2180917 Homologene: 3701

Gene Ontology Molecular Function: • receptor activity • G-protein coupled receptor activity • parathyroid hormone receptor activity Cellular Component: • integral to plasma membrane • membrane Biological Process: • chondrocyte differentiation • osteoblast development • cellular calcium ion homeostasis • signal transduction • G-protein signaling, adenylate cyclase activating pathway • G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) • positive regulation of cell proliferation • negative regulation of cell proliferation • bone mineralization • bone resorption • cell maturation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Entrez

5746

213527

Ensembl

ENSG00000144407

ENSMUSG00000025946

Uniprot

P49190

Q8BUM8

Refseq

NM_005048 (mRNA) NP_005039 (protein)

NM_139270 (mRNA) NP_644676 (protein)

Location

Chr 2: 208.98 - 209.07 Mb

Chr 1: 65.25 - 65.32 Mb

Pubmed search

[1]

[2]

Parathyroid hormone receptor 2, also known as PTH2, is a human protein encoded by the PTHR2 gene.

The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas.

See also

• Parathyroid hormone receptor

Further reading

• Usdin TB, Gruber C, Bonner TI (1995). Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.. J. Biol. Chem. 270 (26): 15455–8.
• Usdin TB, Modi W, Bonner TI (1997). Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization.. Genomics 37 (1): 140–1.
• Clark JA, Bonner TI, Kim AS, Usdin TB (1998). Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors.. Mol. Endocrinol. 12 (2): 193–206.
• Hoare SR, Clark JA, Usdin TB (2000). Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity.. J. Biol. Chem. 275 (35): 27274–83.
• John MR, Arai M, Rubin DA, et al. (2002). Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues.. Endocrinology 143 (3): 1047–57.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
• Seeliger S, Hausberg M, Eue I, et al. (2003). The parathyroid hormone-2 receptor is expressed on human leukocytes and down-regulated in hyperparathyroidism.. Clin. Nephrol. 59 (6): 429–35.
• Bisello A, Manen D, Pierroz DD, et al. (2004). Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization.. Mol. Endocrinol. 18 (6): 1486–98.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14 (10B): 2121–7.
• Mahon MJ, Shimada M (2005). Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.. FEBS Lett. 579 (3): 803–7.

External links

• Parathyroid Hormone Receptors: PTH2. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• MeSH Receptor,+Parathyroid+Hormone,+Type+2

Template:Transmembranereceptor-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.