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peptide YY
Symbol(s): PYY
Locus: 17 q21.1
EC number [1]
EntrezGene 5697
OMIM 600781
RefSeq NM_004160
UniProt P10082

Pancreatic Peptide YY3-36 is a peptide produced in the small intestine and colon that reduces appetite in response to feeding.


Peptide YY3-36 (PYY) is a linear polypeptide consisting of 36 amino acids with structural homology to NPY and pancreatic polypeptide. PYY exerts its action through neuropeptide Y receptors, inhibits gastric motility and increases water and electrolyte absorption in the colon.[1] It is secreted by the gut in response to a meal, and has been shown to reduce appetite.

Relevance to obesity

Leptin also reduces appetite in response to feeding, but obese people develop a resistence to leptin. In contrast, obese people secrete less PYY than normal people do, and in response to added PYY, they reduce their food intake.[2]


  1. Liu C, Aloia T, Adrian T, Newton T, Bilchik A, Zinner M, Ashley S, McFadden D (1996). Peptide YY: a potential proabsorptive hormone for the treatment of malabsorptive disorders.. Am Surg 62 (3): 232-6. PMID 8607584.
  2. Batterham RL et al (September 4, 2003). Inhibition of food intake in obese subjects by peptide YY3-36. New England Journal of Medicine 349 (10): 926-928. PMID 12954742.

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