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Small conductance (SK) calcium-activated potassium channel is a type of Ca2+-activated K+ channels. SK channels are gated by submicromolar-levels of intracellular Ca2+ ions and are important for regulating resting membrane potential, even though SK channels themselves are apparently insensitive to membrane voltage.

SK channels are thought to be involved in synaptic plasticity and can be pharmacologically blocked by a plant-derived neurotoxin Bicuculline

Several SK channel family subunits were cloned (See for example Dr. John Adelman

See also

BK channel IK channel